小剂量红霉素治疗小儿毛细支气管炎的效果

目的研究基层医院使用小剂量红霉素治疗小儿毛细支气管炎的可行性和安全性。方法将广东省江门市新会区第二人民医院收治的毛细支气管炎患儿140例,按照治疗方法分为观察组和对照组,每组各70例。两组患儿同时给予雾化吸入、吸氧、平喘、抗病毒、糖皮质激素等常规治疗,疗程10~14 d。观察组患儿入院的第1天给予红霉素,剂量为10 mg/(kg·d),静脉滴注,1次/d,疗程为5 d。对照组患儿给予等剂量的注射用5%葡萄糖液,1次/d,疗程为5 d。比较两组的治疗总有效率、住院总时间、肺部啰音的消失时间及不良反应发生率。结果观察组总有效率为95.71%,明显高于对照组的82.86%,差异有统计学意义(P<0.05)。观察组肺部啰音的消失时间及住院总时间短于对照组,差异均有统计学意义(P<0.05)。两组患儿在住院期间发生皮疹、呕吐、恶心、腹泻等不良反应发生率比较,差异无统计学意义(P>0.05)。结论基层医院小剂量红霉素治疗小儿毛细支气管炎的疗效好,安全性高,能促使患儿早日康复。

Effect of small dose erythromycin on children with bronchiolitis

Objective To study the efficacy and safety of small dose erythromycin for treatment of children with bronchiolitis in primary hospital.Methods A total of 140 children with bronchiolitis in Guangdong Jiangmen Xinhui District the Sencond People’s Hospital were divided into observation group and control group according to the treatment method,with 70 cases in each group.The two groups were given the conventional treatment with aerosol inhalation,oxygen,asthma,antiviral,glucocorticoid for 10 to 14 days.On the first day of admission,the observation group was given erythromycin,10 times a day,intravenous drip,once a day,for 5 days.The control group was treated with an equivalent amount of 5% glucose solution for injection,once a day,for 5 days.The total effective rate,total hospitalization time,the disappearance time of pulmonary rales and the incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.71%,which was significantly higher than82.86% of the control group,and the difference was statistically significant(P<0.05).The disappearance time of pulmonary rales and total hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of rash,vomiting,nausea,diarrhea and other adverse reactions between the two groups during hospitalization(P>0.05).Conclusion The curative effect of small dose erythromycin in the treatment of children with bronchiolitis in primary hospital was good and high safety,which could promote the early recovery of children.