脑卒中患者肠道菌群与血脂水平的相关性分析

目的研究急性缺血性脑卒中(AIS)患者肠道菌群与血清中甘油三酯和胆固醇的相关性。方法选取2015年5月-2018年1月在天津市环湖医院就诊的30例AIS患者纳入AIS组,另选取同期体检健康志愿者30例纳入HC组。检测两组肠道菌群、血清甘油三酯和胆固醇水平,并分析其相关性。结果 AIS组双歧杆菌属的相对丰度明显高于HC组,霍尔德曼菌属的相对丰度明显低于HC组,差异均有统计学意义(P<0.05);AIS组巨单胞菌属和大肠杆菌-志贺菌与HC组比较,差异均无统计学意义(P>0.05)。AIS组血清中甘油三酯水平明显高于HC组,差异有统计学意义(P<0.05);AIS组血清中胆固醇水平与HC组比较,差异无统计学意义(P>0.05)。巨单胞菌属与胆固醇具有相关性,巨单胞菌属/大肠杆菌-志贺菌与NIHSS和mRS有明显的相关性,双歧杆菌属/大肠杆菌-志贺杆菌与NIHSS均有明显的相关性(均|r|>0.3,均P<0.05)。结论 AIS的患者存在肠道菌群紊乱的情况,其菌属的变化与NIHSS、mRS、血清甘油三酯和胆固醇水平相关。

Correlation analysis of intestinal flora and blood lipid level in patients with acute ischemic stroke

Objective To study the correlation between intestinal flora and serum triglyceride(TG) and cholesterol(CHOL) in patients with acute ischemic stroke(AIS).Methods From May 2015 to January 2018,30 patients with AIS in Tianjin Huanhu Hospital were selected as AIS group,and 30 healthy volunteers in the same period were selected as HC group.The intestinal flora,serum TG and CHOL levels of the two groups were detected,and their correlation was analyzed.Results The relative abundance of Bifidobacterium in AIS group was significantly higher than that in HC group,and the relative abundance of Haldemann was significantly lower than that in HC group,and the differences were statistically significant(P<0.05);there were no significant differences in the genera of macromonas and Escherichia coli-Shigella between AIS group and HC group(P>0.05).The serum TG level of AIS group was significantly higher than that of HC group,and the difference was statistically significant(P<0.05);the serum CHOL level of AIS group was not significantly different from that of HC group(P>0.05).There was a significant correlation between macromonas and CHOL,between macromonas/Escherichiacoli-Shigella and NIHSS and mRS,and between Bifidobacterium/Escherichiacoli-Shigella and NIHSS(all |r|>0.3,all P<0.05).Conclusion Intestinal flora disorder existed in patients with AIS and the bacteria species with significant changes were related to NIHSS,mRS,serum TG and CHOL levels.