肝巨噬细胞调控肝星状细胞活化影响肝纤维化的研究进展＊

肝纤维化是慢性肝病中一种可逆性的损伤修复反应,以肝组织内细胞外基质过度增生与沉积为主要病理表现。活化的肝星状细胞在肝纤维化的进程中发挥着重要作用,其活化受多种因素影响。肝巨噬细胞作为肝脏免疫微环境的重要组成部分,对肝星状细胞的活化、增殖与迁移和细胞外基质的沉积、单核细胞的招募等都有重要意义。相关细胞疗法和中医药可通过调控肝巨噬细胞与肝星状细胞的相关通路及靶点来改善肝纤维化程度。

Research Progress on Regulation of Hepatic Macrophages on the Activation of Hepatic Stellate Cells in Liver Fibrosis

Liver fibrosis is a reversible injury repair process in chronic liver disease, which is characterized by excessive proliferation and deposition of extracellular matrix in liver tissue. Activation of hepatic stellate cells is an important cellular basis of hepatic fibrosis, and the activation response is affected by a variety of stimulating factors. As an important part of hepatic immune microenvironment, hepatic macrophages play an important role in the activation, proliferation and migration of hepatic stellate cells, the deposition of extracellular matrix and the recruitment of monocytes. Both related cell therapy and traditional Chinese medicine therapy can improve the degree of liver fibrosis by regulating the pathways and targets of hepatic macrophages and hepatic stellate cells. This article reviews the molecular mechanism of the effect of hepatic macrophages on the activation of hepatic stellate cells and the regulation of polarization of hepatic macrophages by traditional Chinese medicine in the prevention and treatment of hepatic fibrosis.