| 三七皂甙单体Rb1对动脉平滑肌钙离子内流的影响 |
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| 引用本文： | 贾可亮,林炳鎏,朱卓铨. 三七皂甙单体Rb1对动脉平滑肌钙离子内流的影响[J]. 广州中医药大学学报, 1992, 0(3) |
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| 作者姓名： | 贾可亮 林炳鎏 朱卓铨 |
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| 作者单位： | 广州中医学院核医学研究室，广州中医学院核医学研究室，广州市医药工业研究所 |
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| 摘 要： | 本文用核素~(45)Ca示踪法观察了三七皂甙单体Rb1对兔主动脉平滑肌钙离子内流的影响。结果显示:Rb1(10~(-5)mol/L)对正常营养液的主动脉平滑肌钙离子跨膜流动无明显影响,但对高钾(140mmol/L)或去甲肾上腺素(10~(-5)mol/L)引起的主动脉平滑肌钙离子内流却有明显的抑制作用(P<0.01)。提示三七皂甙Rb1对血管平滑肌有钙拮抗性作用。
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| 关 键 词： | 三七/药理学 @三七皂甙/药理学 主动脉/药物作用 离子通道/药物作用 |
Effect of Panax Notoginseng Saponin Rb1 on Ca~(++) Influxes in Rabbit Aorta |
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| Jia Keliang Zhu Zhuoquan Lin Bingliu. Effect of Panax Notoginseng Saponin Rb1 on Ca~(++) Influxes in Rabbit Aorta[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 1992, 0(3) |
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| Authors: | Jia Keliang Zhu Zhuoquan Lin Bingliu |
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| Affiliation: | Jia Keliang Zhu Zhuoquan Lin Bingliu Department of Nuclear Medicine |
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| Abstract: | Effect of Rb1 (purified saponin of panax notoginseng) on Ca~(++) influxes in the rabbit aorta was studied with radioactive ~(45)Ca. The result showed that Ca~(++) influx of rabbit aorta induced by Rb1 itself in the normal medium was insignificantly different from that of the normal control. But it was found that Rb1 inhibited Ca~(++) influx stimulated by alpha adrenoceptor activation (NE, 10~(-5) mol/L)or by hugh-K~+ (140 mmol/L) depolarization (significantly different from the corresponding control). It is suggested that Rb1 possesses antagonistic action on calcium channels in vascular smooth muscle. |
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| Keywords: | PANAX NOTOGINSENG/pharm @PANAX NOTOGINSENG SAPONINS/pharm AORTA/drug eff ION CHANNELS/drug eff |
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