Effects of a Beta-Receptor Blocking Agent (Propranolol) on Synthesis of IgE in vitro by Peripheral Blood Lymphocytes from Atopic Patients |
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Authors: | Anders,Hovmark Eva,Å sbrink |
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Affiliation: | Department of Dermatology, Södersjukhuset, Stockholm, Sweden |
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Abstract: | Peripheral blood lymphocytes from patients with atopy were studied for IgE production in vitro. Addition of a beta-receptor blocking agent (propranolol) to lymphocytes from 9 of 10 patients with low spontaneous IgE production in vitro caused increased IgE production. In 10 tests with lymphocytes from patients, who were undergoing hyposensitization treatment for cat epithelium and/or birch pollen allergy, no spontaneous in vitro production of the relevant antigen-specific IgE antibodies was detected. However, when propranolol was added to the lymphocyte cultures in vitro, production of antigen-specific IgE antibodies was found. No such production was found when lymphocytes from patients who were not allergic to either of these antigens were studied. Szentivanyi's theory of a partial blockade of beta-adrenergic receptors in atopy and a possible linkage between this theory and the hypotheses of disturbed regulatory functions in the immune system of patients with atopy is discussed. |
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Keywords: | atopy hyposensitization IgE synthesis propranolol |
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