| 降纤酶对Ⅱ型糖尿病并发脑梗塞患者胰岛素敏感指数与高凝状态指标的影响 |
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| 引用本文： | 谌剑飞,梁浩荣,马雅玲.降纤酶对Ⅱ型糖尿病并发脑梗塞患者胰岛素敏感指数与高凝状态指标的影响[J].放射免疫学杂志,1999(5). |
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| 作者姓名： | 谌剑飞 梁浩荣 马雅玲 |
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| 作者单位： | 广州中医药大学附属珠海中医院省神经内分泌重点专科!（珠海!519015）(谌剑飞，梁浩荣)，重点专科神经内分泌实验室(马雅玲) |
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| 基金项目： | 广州中医药大学科研课题(No.98001) |
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| 摘 要： | 目的:观察降纤酶在治疗Ⅱ型糖尿病并发急性脑梗塞时对胰岛素敏感指数(ISI)、血小板聚集率(PAgT)、纤维蛋白原(FG)、体外血栓长度(VTL)及活化部分凝血活酶时间(APTT)水平的影响,并探讨其作用机制。方法:采用放射免疫分析(RIA)等法对该药治疗前后上述指标含量进行检测,并与健康人组作对照。结果:经降纤酶治疗后本组病例的ISI明显升高(p<0.01),并与血凝程度下降呈正比关系。结论:降纤酶治疗Ⅱ型糖尿病合并急性脑梗塞的作用机制除抗凝溶栓作用外,可能还与其调整胰岛素抵抗等因素有关。
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| 关 键 词： | 糖尿病 脑梗塞 降纤酶 胰岛素敏感性 药理学 |
EFFECT OF DEFIBRASE ON ISI AND HYPER - COAGUABELITY PARAMETERS IN II DM PATIENTS COMPLICATED WITH CEREBRAL INFARCTION |
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| Chen Jianfei Ma Yaling liang Haorong The Affilited Zhuhai TCM Hospital of GangZhou University of TCM,Zhuhai.EFFECT OF DEFIBRASE ON ISI AND HYPER - COAGUABELITY PARAMETERS IN II DM PATIENTS COMPLICATED WITH CEREBRAL INFARCTION[J].Journal of Radioimmanology,1999(5). |
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| Authors: | Chen Jianfei Ma Yaling liang Haorong The Affilited Zhuhai TCM Hospital of GangZhou University of TCM Zhuhai |
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| Abstract: | To investigate the effect and mechanism of action of defibrase on ISI, PAgT, FG, VTL and APTT during treatment of II DM patients complicated with acute cerebral infarction.Method: The above - mentioned parameters were deternined with RIA both before and after treat-mant,with healthy subjects as controls.Result: The ISI readings were significantly increased after treatment (p < 0.01) and were positively correlated to the decrease of hypercoaguability.Conclusion: Besides anti - hypercoagulation and thrombolysis, the beneficial action of defibrase treatment may be related to its modulation of IS as well. |
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| Keywords: | diabetes mellitus cerebral infarction defibrase insulin sensitivity phamacology |
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