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Peripartum Cardiomyopathy: an Update
Authors:Feriel Azibani  Karen Sliwa
Affiliation:1.Hatter Institute for Cardiovascular Research in Africa, Faculty of Health Sciences,University of Cape Town,Cape Town,South Africa;2.Mary McKillop Institute,ACU,Melbourne,Australia
Abstract:

Purpose of Review

Peripartum cardiomyopathy (PPCM) is an idiopathic disorder defined as heart failure occurring in women during the last month of pregnancy and up to 5 months postpartum. In this review, we outline recent reports about the disease pathogenesis and management and highlight the use of diagnosis and prognosis biomarkers.

Recent Findings

Novel data strengthen the implication of endothelial function in PPCM pathogenesis. The first international registry showed that patient presentations were similar globally, with heterogeneity in patient management and outcome.

Summary

Despite large improvement in patient management and treatment, there is still a sub-group of women who die from PPCM or who will not recover their cardiac function. Remarkable advances in the comprehension of disease incidence, pathogenesis, and prognosis could be determined with multi-center and international registries.

Clinical Trials

ClinicalTrials.gov Identifier: NCT02590601
Keywords:
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