我院2009~2011年821例药品不良反应报告分析

目的：了解本院药品不良反应（ADR）发生的特点及规律，为临床安全及合理用药提供参考。方法对本院2009~2011年上报的821例ADR报告分别从患者年龄、药品种类、给药途径、ADR临床表现等方面进行回顾性分析与评价。结果821例ADR 报告中女性略多于男性，中青年患者发生居多；静脉用药引起的ADR最多（618例，占75.09%）；引起ADR最多的药物为抗菌药物（428例，占52.13%）；ADR临床表现主要为皮肤及其附件损害（451例，占50.84%）。结论应加强ADR监测及其相关知识的宣传，规范临床合理用药，减少ADR的发生。

Analysis of 821 cases of adverse drug reaction in our hospital during 2009~2011

Objective To investigate the general information and characteristics of adverse drug reaction in our hospital and provide reference for rational drug use in clinic.MethodsA total of 821 ADR cases reported by our hospital from 2009 to 2011 were analyzed retrospectively with regard to age, drug varieties, routes of administration, clinical manifestation of ADR.ResultsOf the 821 ADR cases, the incidence rate in female was higher than that in male. The young and middle-aged have the most. Intravenous drip accounted for 75.09%. Anti-infectious drugs （52.13%） occupied mostly in the incidence of ADR. Lesions of skin and its appendants were the main clinical manifestations.ConclusionGreat importance should be attached to ADR monitoring in order to reduce the incidence of ADR. It is necessary to strengthen ADR monitoring and publicizing of ADR-related knowledge to guide the clinical rational use of drugs and reduce the repetitive occurrence of ADR.