Genomic sequences of HLA‐A*68:169, HLA‐B*07:298 and HLA‐B*39:129. |
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| Authors: | A Balas D Planelles M Rodríguez‐Cebriá N Puig J L Vicario |
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| Institution: | 1. Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spain;2. Histocompatibilidad, Centro de Transfusión de la Comunidad Valenciana, Valencia, Spain |
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| Abstract: | Three new HLA class I alleles were described in the Spanish population. HLA‐A*68:169 and ‐B*39:129 show one amino acid replacement at the α1‐domain, compared to A*68:02 (P47 > L47) and ‐B*39:06 (S11 > A11), respectively. HLA‐B*07:298 presents one nucleotide mutation within exon 1, resulting in a new amino acid position ?14, L>Q, which has not been previously described in any HLA protein. Prediction of the B*07:298 signal peptide cleavage did not show significant differences in comparison with that obtained for the rest of HLA‐B genes. |
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| Keywords: | HLA class I new alleles sequencing |
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