| Effects of dl-praeruptorin A on nucleus factor-κB and tumor necrosis factor-α expression in ischemia-reperfusion hearts |
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| 作者姓名： | Chi WANG Tian-hui CHANG Xin-hua ZHANG Huai-liang WANG |
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| 作者单位： | Chi WANG，Tian-hui CHANG，Xin-hua ZHANG，Huai-liang WANG Department of Clinical Pharmacology，China Medical University，Shengyang 110001，China |
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| 基金项目： | ProjectpartlysupportedbytheKeyFoundationoftheMinistryofPublicHealthofChina,№88402257. |
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| 摘 要： | AIM: To study the effects of dl-praeruptorin A (Pd-Ia) on nucleus factor-κB (NF-κB) activativity and tumor necrosis factor-α(TNF-α)expression in ischemia-reperfusion (I/R) myocardium. METHODS: Langendorff's isolated rat heart was subjected to a 10-min ischemia followed by a 30-min reperfusion. NF-κB activity in nucleus was analyzed by Sandwich Enzyme-Linked Immunosorbent Assay (ELISA). TNF-α level in cytoplasm was measured by
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| 关 键 词： | 前胡甲素 心肌缺血 缺血再灌注 细胞因子 肿瘤坏死因子 核因子-κB |
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