| Abstract: | OBJECTIVE: At present, platelet-rich fibrin is widely used in site retention after tooth extraction, but the effect of platelet-rich fibrin in alveolar ridge preservation is not very clear compared with other materials. This study evaluated the effect of applied platelet-rich fibrin in the preservation of alveolar ridge after tooth extraction to provide theoretical basis for clinical application of platelet-rich fibrin to reduce alveolar bone resorption. METHODS: Up to June 2020, all clinical randomized controlled studies on platelet-rich fibrin for alveolar ridge preservation, including platelet-rich fibrin alone and platelet-rich fibrin combined with heterogeneous bone, were collected by using The Cochrane Library, PubMed, Web of science core set, EMbase, CNKI, and Wanfang databases. Two researchers extracted data from the retrieved documents and used Cochrane bias risk assessment tools to evaluate the bias risk included in the study. RevMan 5.3 software was used for meta-analysis. RESULTS: (1) Totally 159 articles were retrieved, and 11 randomized controlled trials were finally included, involving 531 patients and 575 implants. (2) The results of meta-analysis showed that the difference in the height absorption of tooth alveolar bone was not statistically significant when platelet-rich fibrin was applied alone (SMD=-0.38, 95%CI:-0.83 to-0.06, P > 0.05). There were significant differences between platelet-rich fibrin composite heterogeneous bone and simple xenogeneic bone in alveolar bone resorption height (3 months: SMD=-1.40, 95%CI:-1.79 to-1.01, P < 0.05; 6 months: SMD=-1.37, 95%CI:-1.68 to-1.06, P < 0.05), alveolar bone resorption width at 3 and 6 months after tooth extraction (SMD=-0.18, 95%CI:-0.25 to-0.11, P < 0.05), and mouth mucosa healing rate at 2 weeks after tooth extraction (SMD=9.90, 95%CI:8.61-11.19, P < 0.05). CONCLUSION: Applying platelet-rich fibrin composite heterogeneous bone after tooth extraction can remarkably reduce the resorption of alveolar bone both in height and width and accelerate soft tissue healing. Because of the small sample size included in the study, clinical studies with a large sample size are needed to verify the above conclusions. © 2022, Publishing House of Chinese Journal of Tissue Engineering Research. All rights reserved. |
