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Oxidative stress in obstructive sleep apnea
Authors:Yamauchi Motoo  Nakano Hiroshi  Maekawa Junko  Okamoto Yukinori  Ohnishi Yoshinobu  Suzuki Takahiro  Kimura Hiroshi
Affiliation:Department of Internal Medicine, Tenri City Hospital, 300-11 Tomido-cho, Tenri City, Nara 632-0072, Japan. mountain@pastel.ocn.ne.jp
Abstract:STUDY OBJECTIVES: To investigate the relationship between the severity of obstructive sleep apnea (OSA) and oxidative stress, which plays an important role in the pathogenesis of cardiovascular disease, and to elucidate the factors contributing to this relationship. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 128 consecutive subjects referred to the sleep laboratory of our hospital for screening or treatment of OSA. INTERVENTIONS: Not applicable. MEASUREMENTS: The severity of sleep-disordered breathing was evaluated by polysomnography. We measured urinary excretion of 8-hydroxy-2'-deoxyguanosine (8-OHdG) as an in vivo parameter of oxidative stress. Known risk factors for oxidative stress (age, obesity, smoking, hyperlipidemia, hypertension, and diabetes mellitus) were also investigated. RESULTS: Seventy subjects had nonsevere OSA (an apnea-hypopnea index [AHI] < 30), and 58 subjects had severe OSA (AHI >or= 30). Urinary 8-OHdG excretion was significantly higher in the severe OSA group (p = 0.03). Furthermore, urinary 8-OHdG excretion was significantly correlated with parameters of sleep-disordered breathing, including AHI, the apnea index, the oxygen desaturation index (ODI), the duration of oxygen saturation < 90%, and the respiratory arousal index. However, only ODI was significantly correlated with urinary 8-OHdG excretion after adjustment for confounding factors that are considered to be related to oxidative stress. CONCLUSIONS: The severity of OSA is independently associated with oxidative stress. Among various sleep-disordered breathing parameters, ODI is most closely related to oxidative stress.
Keywords:8-hydroxy-2′-deoxyguanosine  ischemia-reperfusion injury  obstructive sleep apnea syndrome  oxidative stress  AHI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw60"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  apnea-hypopnea index  AI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw80"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  apnea index  BMI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw100"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  body mass index  DBP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw120"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  diastolic BP  ELISA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw140"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  enzyme-linked immunosorbent assay  ESS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw160"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Epworth sleepiness scale  glycosylated hemoglobin  ODI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw200"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  oxygen desaturation index  8-OHdG"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw220"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  8-hydroxy-2′-deoxyguanosine  OSA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw240"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  obstructive sleep apnea  ROS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw260"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  reactive oxygen species  SBP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw280"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  systolic BP  SDB"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw300"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  sleep-disordered breathing  T90"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw320"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  the duration of an oxygen saturation below 90% and expressed it as a percentage of the total sleep time  T-chol"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  cekeyw350"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  total cholesterol
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