2016年某院金黄色葡萄球菌感染分布及耐药性分析

目的 对2016年秦皇岛市第一医院患者金黄色葡萄球菌感染情况及耐药特点进行调查,为感染监控和临床用药提供参考.方法 回顾性分析2016年住院患者细菌培养标本中金黄色葡萄球菌的分离情况及耐药性.结果 共分离金黄色葡萄球菌311株,其中耐甲氧西林金黄色葡萄球菌(MRSA) 108株,占34.7％.金黄色葡萄球菌感染的标本来源主要有痰液(46.95％)、分泌物(34.73％)和全血(9.64％);感染科室主要以重症监护室、神经外科、儿科、老年病科、骨科多见.药物敏感性试验结果显示,MRSA耐药率明显高于甲氧西林敏感金黄色葡萄球菌(MSSA),未发现对万古霉素、替加环素耐药的菌株,对利奈唑胺和喹努普汀/达福普汀、呋喃妥因的敏感率也很高,但对克林霉素、红霉素耐药率达70％以上,而对青霉素的耐药率高达97.1％.结论 甲氧西林敏感金黄色葡萄球菌(MSSA)对部分抗菌药物仍保持较好的敏感性,而MRSA表现为多重药耐药性,应引起临床高度重视,临床应根据药物敏感性试验结果合理使用抗菌药物.

Investigation of Staphylococcus Aureus Infection Among Inpatients in a Hospital in 2016 and Analysis of Its Drug Resistance

Objective To investigate the status of Staphylococcus aureus infection in the First Hospital of Qinhuangdao in 2016 and its drug resistance in order to provide reference for clinical medication.Methods The retrospective analysis was performed on the isolation condition and the drug resistance of Staphylococcus aureus from the bacterial culture from the inpatient samples of our hospital in 2016.Results A total of 311 strains of Staphylococcus aureus were isolated,including 108 strains (34.7％)of methicillin-resistant Staphylococcus aureus (MRSA).The main sources of the samples with Staphylococcus aureus infection were sputum (46.95 ％),secretion (34.73 ％)and blood(9.64％);while the main departments with Staphylococcus aureus infection were ICU,neurosurgery,orthopedics,pediatric and geriatrics.The results of drug susceptibility showed that the drug resistance rate of MRSA was significantly higher than that of methicillin-sensitive Staphylococcus aureus (MSSA),and no strains resistant to vancomycin and tigecycline were found.The sensitivity rate is also high to linezolid,quinupristin /dafoe leptin and nitrofurantoin.But to clindamycin,erythromycin,the resistance rate was above 70％,and the resistance rate to penicillin was as high as 97.1％.Conclusion Methicillin sensitive Staphylococcus aureus (MSSA)remains sensitive to some antibiotics,while MRSA showed multiple drug resistance.Clinicians should pay more attention to the clinical rational for usage of antibiotics according to drug susceptibility test results.