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随机尿微量白蛋白/肌酐比值的半定量试纸条法的临床评价
引用本文:刘竞争,黄泽玉,陈燕,钱芳,李冉冉,李根,王晨璐,马瑞敏,张国军.随机尿微量白蛋白/肌酐比值的半定量试纸条法的临床评价[J].标记免疫分析与临床,2018,25(4):569-573.
作者姓名:刘竞争  黄泽玉  陈燕  钱芳  李冉冉  李根  王晨璐  马瑞敏  张国军
作者单位:首都医科大学附属北京天坛医院检验科,北京100050;北京市免疫试剂临床工程技术研究中心,北京100050;首都医科大学附属友谊医院新华医院,北京,101199
基金项目:北京市优秀人才青年拔尖个人项目(2015000021223ZK34)
摘    要:目的 评价半定量试纸条法检测随机尿微量白蛋白/肌酐比值(ACR)方法学性能.方法 选取2016年12月至2018年3月2288份随机尿标本,分别通过全自动生化分析仪和半定量试纸条法检测ACR,分析比较两种方法学检测结果的差异.结果 半定量试纸条法检测方法与全自动生化分析仪定量检测方法之间成正相关(r =0.577,P<0.01).半定量试纸条检测法的灵敏度为90.7%,特异性为66.7%.假阳性率为37.0%,假阴性率为8.3%.结论 半定量试纸条法存在假阳性率和假阴性率,可结合定量方法作为一种筛查方法.

关 键 词:尿试纸条  尿肌酐  尿白蛋白/肌酐

The Clinical Evaluation of Semi-Quantitative Dipstick of Urine ACR
LIU Jing-zheng,HUANG Ze-yu,CHEN Yan,QIAN Fang,LI Ran-ran,LI Gen,WANG Chen-lu,MA Rui-min,ZHANG Guo-jun.The Clinical Evaluation of Semi-Quantitative Dipstick of Urine ACR[J].Labeled Immunoassays and Clinical Medicine,2018,25(4):569-573.
Authors:LIU Jing-zheng  HUANG Ze-yu  CHEN Yan  QIAN Fang  LI Ran-ran  LI Gen  WANG Chen-lu  MA Rui-min  ZHANG Guo-jun
Abstract:Objective To evaluate the performance of semi-quantitative dipstick of the random urinary albumin -creatinine ratio (ACR).Methods 2288 cases of hospitalized patients with random urine specimen were tested by the semi-quantitative dipstick and automatic biochemical analyzer,before comparing the ACR results of the two methods.Results A positive correlation between semi-quantitative dipstick and quantitative detection method of automatic biochemical analyzer with correlation coefficient of 0.577was observed (P < 0.01).The sensitivity of the semi-quantitative dipstick was 90.7%,while the specificity was 66.7%.The false positive rate was 37.0%,and the false negative rate was 8.3%.Conclusion Semi-quantitative dipstick has certain percentages of false positive case and false negative case.As a screening method,it should be combined with quantitative method.
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