Bone remodeling during pregnancy and post-partum assessed by metal lead levels and isotopic concentrations |
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| Affiliation: | 1. Department of Environmental Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, Australia;2. Commonwealth Scientific and Industrial Research Organisation (CSIRO), Energy Flagship, Sydney, Australia;3. Department of Psychology, Macquarie University, Australia;4. Garvan Institute of Medical Research, St Vincent''s Hospital, School of Medicine Sydney, University of Notre Dame Australia, Sydney, NSW, Australia;5. University of New South Wales, Garvan Institute of Medical Research, St Vincent''s Hospital, School of Medicine Sydney, Sydney, NSW, Australia;1. Soroka University Medical Center, Endocrinology Unit, Beer-Sheva, Israel;2. Soroka University Medical Center, Clinical Research Center, Beer-Sheva, Israel;3. Soroka University Medical Center, Department of Otorhinolaryngology and Head and Neck Surgery, Beer-Sheva, Israel;1. Department of Radiology, The Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province, China;2. Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;3. Department of Preventive Medicine, Zuiyi Medical College, Zunyi, Guizhou Province, China;4. Institute of Radiation Medicine, Fudan University, Shanghai, China;5. Department of Occupation Medicine, School of Public Health, Fudan University, Shanghai, China;1. Université de Lille, EA 4490 PMOI, F-59000 Lille, France;2. Faculté de Chirurgie Dentaire, Place de Verdun, F-59000 Lille, France;3. Service d''Odontologie, Centre Abel Caumartin, CHRU de Lille, F-59000 Lille, France;4. Service de Rhumatologie, Hôpital Roger Salengro, CHRU de Lille, F-59000 Lille, France |
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| Abstract: | Bone remodeling is normally evaluated using bone turnover markers/indices as indicators of bone resorption and formation. However, during pregnancy and post-partum, there have been inconsistent results between and within biomarkers for bone formation and resorption. These differences may relate to pregnancy-related changes in metabolism and/or hemodilution altering measured marker levels. An alternative approach to evaluating bone remodeling is to use the metal lead (Pb) concentrations and Pb isotopic compositions in blood. These measurements can also provide information on the amount of Pb that is mobilized from the maternal skeleton. Despite some similarities with accepted bone turnover markers, the Pb data demonstrate increased bone resorption throughout pregnancy that further continues post-partum independent of length of breast-feeding, dietary intake and resumption of menses. Furthermore the isotopic measurements are not affected by hemodilution. These data confirm calcium balance studies that indicate increased bone resorption throughout pregnancy and lactation. They also indicate potentially major public health implications of the transfer of maternal Pb burden to the fetus and new born. |
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