| 环氧化酶2、血管内皮生长因子C/血管内皮生长因子受体3与肺癌淋巴转移 |
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| 引用本文： | 王东昌,陈刚. 环氧化酶2、血管内皮生长因子C/血管内皮生长因子受体3与肺癌淋巴转移[J]. 国际呼吸杂志, 2009, 29(8). DOI: 10.3760/cma.j.issn.1673-436X.2009.008.011 |
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| 作者姓名： | 王东昌 陈刚 |
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| 作者单位： | 河北医科大学第三医院呼吸内科,石家庄,050051;河北医科大学第三医院呼吸内科,石家庄,050051 |
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| 摘 要： | 淋巴转移是肺癌转移途径之一.在肺癌淋巴转移过程中,血管内皮生长因子及其受体家族发挥了重要的作用.尤其是淋巴内皮特异性受体血管内皮生长因子受体3及其配体血管内皮生长因子C对促进淋巴管生长具有关键的作用.同时近年研究表明环氧化酶2与肺癌淋巴转移呈正相关.环氧化酶2、血管内皮生长因子C/血管内皮生长因子受体3有望成为肺癌淋巴管转移靶向治疗的新靶点.
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| 关 键 词： | 环氧化酶2 血管内皮生长因子C 血管内皮生长因子受体3 肺癌 淋巴转移 |
Progress in cyclooxygenase-2-vascular endothelial growth factor-C/vascular endothelial growth factor receptor-3 and lymphatic metastasis of lung caner |
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| WANG Dong-chang,CHEN Gang. Progress in cyclooxygenase-2-vascular endothelial growth factor-C/vascular endothelial growth factor receptor-3 and lymphatic metastasis of lung caner[J]. International Journal of Respiration, 2009, 29(8). DOI: 10.3760/cma.j.issn.1673-436X.2009.008.011 |
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| Authors: | WANG Dong-chang CHEN Gang |
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| Abstract: | Lymphatic metastasis is one of metastasis routes in lung cancer.Vascular endothelial growth factors(VEGFs)and their receptors(VEGFRs) play important roles during the process of lymphatic metastasis.Particularly,VEGFR-3 and its ligand VEGF-C play crucial roles in promoting lymphatic vascular growth.Recent researches have demonstrated that there is a positive correlation between cyclooxygenase-2 and lymphatic metastasis of lung cancer.It would be a new method of targeted therapy in lymphatic metastasis of lung cancer to target cyclooxygenase-2,VEGF-C/VEGFR-3. |
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| Keywords: | Cyclooxygenase-2 Vascular endothelial growth factor-C Vascular endothelial growthfactor receptor-3 Lung cancer Lymphatic metastasis |
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