丹参对门脉高压大鼠胃粘膜及肝脏的影响

用丹参对肝硬变门脉高压大鼠进行了治疗，并与心得安进行了比较。结果表明，丹参和心得安均可使门脉压力下降，胃粘膜前列腺素Ｅ２含量、胃粘膜血流量和胃壁结合粘液量增加。但心得安使肝细胞坏死加重，血清ＡＬＴ和ＴＢ不能降低，ＡＬＴ反有升高。而丹参可使肝细胞损害减轻，肝内纤维组织减少，ＡＬＴ、ＡＬＰ和ＴＢ降至正常水平。说明心得安虽可使门脉高压性胃粘膜病变改善，却可加重肝损害。而丹参不仅可使胃粘膜病变改善，而且还能改善肝功，促进肝纤维吸收。

EFFECTS OF SALVIAE MILTIORRHIZAE ON GASTRIC MUCOSA AND LIVER IN PORTAL HYPERTENSIVE RATS

Experiments were performed in the CCl4-induced portal hypertensive rats to study effects of salviae miltiorrhizae on portal hypertensive gastric mucosal lesions. In salviae miltiorrhizae group and propranolol group, portal vein pressure was significantly lower and gastric mucosal prostagandin E2 content, gastric mucosal blood flow and gastric adherent mucus were significantly higher than that in portal hypertension control group. The pathology in salviae miltiorrhizae group showed decreased intrahepatic proliferative fibrous tissue and lowered serum ALT, ALP and TB as compared with those in portal hypertension control group. The intrahepatic proliferative fibrous tissue in propranolol group did not differ from that with portal hypertension control group, but it showed even more marked hepatocellular degeneration and necrosis and elevation of serum ALP. The above data indicate that salviae militiorrhizae can improve the functions of gastric mucosa and liver, and therefore can be employed for treating portal hypertensive gastric mucosal lesions.