| 促红细胞生成素对大鼠脑缺血再灌注损伤的保护作用 |
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| 引用本文： | 杨建学,赵勇刚,刚光霞.促红细胞生成素对大鼠脑缺血再灌注损伤的保护作用[J].陕西医学杂志,2007,36(10):1284-1285,1296. |
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| 作者姓名： | 杨建学 赵勇刚 刚光霞 |
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| 作者单位： | 河南科技大学第一附属医院,洛阳,471003 |
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| 摘 要： | 目的:探讨促红细胞生成素(Epo)对大鼠局灶性脑缺血再灌注后脑损伤的保护作用。方法:20只雄性SD大鼠,采用线栓法阻断大鼠一侧大脑中动脉(MCA)血流2h,再灌注48h制成局灶性脑缺血再灌注损伤模型。随机分为两组,治疗组于再灌注前经腹腔注射Epo(3000U/kg),对照组给予等量生理盐水腹腔注射,48h后断头取脑。制作2mm冰冻切片;以2%氯化-2,3,5三苯基四氮唑(TTC)对脑切片进行染色;经图像分析仪计算梗死体积占全脑体积的百分比。结果:治疗组脑梗死体积与对照组相比明显缩小(P<0.01)。结论:Epo能够显著缩小脑梗死体积,对脑缺血再灌注损伤有良好的保护作用。
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| 关 键 词： | 脑缺血 再灌注损伤/预防与控制 促红细胞生成素/治疗应用 |
| 修稿时间： | 2007-02-08 |
Effects of erythropoietin on neural cells in rats aiter ischemia -reperfusion injury |
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| Yang Jianxue,Zhao Yonggang,Gang Guangxia.Effects of erythropoietin on neural cells in rats aiter ischemia -reperfusion injury[J].Shaanxi Medical Journal,2007,36(10):1284-1285,1296. |
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| Authors: | Yang Jianxue Zhao Yonggang Gang Guangxia |
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| Institution: | I.uoyang 471003 |
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| Abstract: | Objective: To investigate the effects of erythropoietin on neural cells in rats after ischemia-reperfusion injury.Methods: 20 male SD rats were divided with two groups randomly.One group rats were injected with erythropoietin(Epo),the other group rats were injected with NS equally.And their single middle cerebral arteries(MCA) were all occluded for 2h and reperfused for 48h for making focal cerebral ischemia-reperfusion injury.Then,their brains were removed,cut into slices and stained and,the cerebral infarction volume and percentage were measured and calculated.Results: The cerebral infarction volume of those rats which received Epo was significantly smaller than those which received NS.Conclusion:Epo can reduce the cerebral infarction volume.Epo can a protective effect on cerebral ischemia-reperfusion injury. |
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| Keywords: | Brain ischemia Reperfusion injury/prevention & contropl Erythropoietin/therapeutic |
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