| 抗过敏药盐酸奥洛他定的合成工艺研究 |
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| 引用本文： | 薛建英,陈泠,谭国良,张瑞华,陈国良. 抗过敏药盐酸奥洛他定的合成工艺研究[J]. 中国药物化学杂志, 2004, 14(6): 363-364,367 |
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| 作者姓名： | 薛建英 陈泠 谭国良 张瑞华 陈国良 |
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| 作者单位： | 1. 沈阳药科大学制药工程学院,辽宁,沈阳,110016
2. 湖南株洲千金湘江药业公司,湖南,株洲,412008 |
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| 摘 要： | 目的合成新型抗过敏药盐酸奥洛他定.方法以对羟基苯乙酸和苯酞为原料,经亲核取代、脱水环合、Wittig反应、成盐制备盐酸奥洛他定.结果目标化合物的结构经氢谱、质谱确证,总收率约5.9%.结论改进了合成路线,为进一步工业生产和临床应用打下基础.
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| 关 键 词： | 药物化学 制备 化学合成 盐酸奥洛他定 抗过敏 |
| 文章编号： | 1005-0108(2004)06-0363-02 |
Study on the synthetic process of a novel anti-allergic agent olopatadine hydrochloride |
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| XUE Jian ying ,CHEN Ling ,TAN Guo liang ,ZHANG Rui hua ,CHEN Guo liang. Study on the synthetic process of a novel anti-allergic agent olopatadine hydrochloride[J]. Chinese Journal of Medicinal Chemistry, 2004, 14(6): 363-364,367 |
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| Authors: | XUE Jian ying CHEN Ling TAN Guo liang ZHANG Rui hua CHEN Guo liang |
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| Affiliation: | XUE Jian ying 1,CHEN Ling 1,TAN Guo liang 1,ZHANG Rui hua 2,CHEN Guo liang 1 |
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| Abstract: | Aim To synthesize a novel anti allergic agent olopatadine hydrochloride.Methods Starting from the starting material 4 hydroxyphenylacetic acid.Olopatadine hydrochloride was synthesized via nucleophilic substitution,cyclization,Wittig reaction,salt formation.Results The structure of the target compound was confirmed by MS, 1H NMR,the overall yield was 5.9%.Conclusions The synthetic process of olopatadine hydrochloride is improved and suitable for industrial manufacture. |
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| Keywords: | medicinal chemistry preparation chemical synthesis olopatadine hydrochloride antiallergic |
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