T-2 toxin effect on bacterial infection and leukocyte functions |
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| Authors: | R Yarom Y Sherman R More I Ginsburg R Borinski B Yagen |
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| Affiliation: | 1. Department of Pharmacology and Experimental Therapeutics, Louisiana State University Medical Center, 1901 Perdido Street, New Orleans, Louisiana 70112 USA;2. Department of Anesthesiology, University of Texas Medical School, P.O. Box 20708, Houston, Texas 77225 USA;3. Department of Environmental Health, SC-34, University of Washington, Seattle, Washington 98195 USA |
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| Abstract: | The effects of T-2 toxin on bacterial infection and leukocyte function and structure were examined in vivo and in vitro. Rats were innoculated with staphylococci after pretreatment with or without T-2 toxin. The T-2 pretreated rats failed to mount a cellular response to the bacteria. Blood and bone marrow cells were markedly suppressed by the T-2 toxin, the myeloid series being the most affected. In vitro studies with human leukocytes showed that small, nonkilling doses of T-2 toxin inhibited chemotaxis, chemiluminescence stimulated by bacteria, and phagocytosis of bacteria. It was concluded that this inhibition may contribute towards sepsis and rapid onset of death in T-2 toxin poisoning. |
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| Keywords: | To whom correspondence should be addressed. |
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