卡托普利对CHF患者MMP-9/TIMP-1水平和BNP的干预作用

目的观察卡托普利对CHF患者MMP-9/TIMP-1水平和BNP的影响。方法将181例患者随机分为2组。对照组94例予洋地黄药物、β-受体阻滞剂、利尿剂等的基础治疗;治疗组87例,加用卡托普利片25mg日三次口服,视患者情况调整药物用量。2组患者均于治疗前和治疗8周后,分别测定血清MMP-9、TIMP-1、BNP含量。结果与治疗前相比,治疗后两组的MMP-9、MMP-9/TIMP-1、BNP含量均有明显降低(P<0.05),但治疗组的降低更明显(P<0.05)。结论卡托普利可以降低心衰患者MMP-9、MMP-9/TIMP-1含量,从而降低血清BNP水平,改善心功能。

Effect of Captopril on Serum Levels of MMP-9/TIMP-1 and BNP in Patients with Congestive Heart Failure

Objective To observe the effect of captopril on serum levels of MMP-9,TIMP-1 and BNP in patients with congestive heart failure.Methods 181 cases of patients were randomly divided into 2 groups:94 cases in control group were treated basically with digitalis,β-blockers and diuretics;87 cases in treatment group were treated additionally with 25 mg captopril tablets orally three times a day,dosage adjustment with diseases' development.Serum levels of MMP-9,TIMP-1 and BNP in patients in the two groups were determined respectively before treatment and eight weeks later.Results In contrast to pre-treatment,serum levels of MMP-9,TIMP-1 and BNP in patients after treat ment in the two groups were significantly lower(P <0.05),but the reduction in the treatment group was more obvious(P <0.05).Conclusion Captopril can reduce serum levels of MMP-9,MMP-9/TIMP-1 in patients with heart failure,thereby reducing the serum BNP levels to improve heart function.