雷公藤内酯醇半合成衍生物对人结肠癌细胞系荷瘤小鼠肿瘤抑制作用的研究

目的:观察和评价雷公藤内酯醇的半合成衍生物(MC002)对人结肠癌HCT-8小鼠模型的肿瘤抑制作用。方法:用BALB/C裸小鼠接种人结肠癌HCT-8瘤株造成小鼠肿瘤模型,以MC002对荷瘤小鼠的相对肿瘤增殖率、瘤重、抑瘤率为指标评价MC002对小鼠的抑瘤作用。结果:MC002各剂量组瘤体积明显小于模型对照组,瘤重均显著降低,在1.5mg.kg^-1、1.0mg·kg^-1给药10次后T/C%均小于40%(P<0.05),且具有量效关系。结论:MC002能有效抑制人结肠癌HCT-8荷瘤小鼠体内肿瘤生长。通过深入研究MC002有可能发展成为一种新型抗癌药。

Anti-tumor Activity of the Semi-synthesis Derivative of Triptolide on Mice with Transplanted Human Colonic Tumor Cells

Objective:To observe and evaluate the anti-tumor effect of MC002,the semi synthesis derivative of triptolide,on human colonic tumor in HCT-8 mice.Methods: BALB/c nude mice of human colonic tumor model was made through HCT-8 cells inoculation.Anti-tumor activity of MC002 was evaluated in terms of relative tumor growth rate,tumor weight and tumor inhibitory ratio in mice transplanted.Results: Tumor volume and weight in every MC002 dosage group were obviously smaller than that in the control group.after ten times of administration,the values of T/C% in the groups of 1.5 mg·kg^-1 and 1.0 mg·kg^-1 were less than 40% with dose-effect relation ship.Conclusion:MC002 has significant restraining effect on the growth of HCT-8 tumor in mice.It may be developed into a new promising anticancer drug through further studies.