蛋白琥珀酸铁口服溶液联合益血生胶囊治疗妊娠期缺铁性贫血疗效评价

目的探讨蛋白琥珀酸铁口服溶液联合益血生胶囊治疗妊娠期缺铁性贫血(IDA)的疗效及对铁代谢指标和免疫功能的影响。方法选择2018年1月至12月医院收治的妊娠期IDA患者198例,按随机数字表法分为对照组和观察组,告99例。对照组患者给予蛋白琥珀酸铁口服溶液治疗,观察组患者在此基础上加用益血生胶囊治疗。两组均连续治疗4周。结果观察组临床总有效率为97.98%,明显高于对照组的77.78%(χ2=18.966,P=0.000)。治疗后,两组红细胞平均体积(MCV)、平均血红蛋白量(MCH)、血红蛋白(Hb)均明显高于治疗前(P<0.05)红细胞体积分布宽度(RDW)均明显低于治疗前(P<0.05),且观察组以上指标均明显优于对照组(P<0.05);两组血清铁蛋白(SF)、血清铁(SI)水平均明显高于治疗前(P<0.05),血清转铁蛋白受体(sTFR)、总铁结合力(TIBC)水平均明显低于治疗前(P<0.05),且观察组以上指标均明显优于对照组(P<0.05);两组外周血CD4+水平和CD4+/CD8+均明显高于治疗前(P<0.05),外周血CD8+水平均明显低于治疗前(P<0.05),且观察组以上指标均明显优于对照组(P<0.05)。观察组治疗期间的不良反应发生率为4.04%,与对照组的3.03%相当(χ2=0.148,P=0.700)。结论蛋白琥珀酸铁口服溶液联合益血生胶囊治疗妊娠期IDA的临床疗效显著,能明显改善贫血症状,提高机体免疫功能,且安全性较好。

Protein Iron Succinate Oral Solution Combined with Yixuesheng Capsules on Iron Deficiency Anemia During Pregnancy

Objective To explore the efficacy of protein iron succinate oral solution combined with Yixuesheng Capsules on iron deficiency anemia(IDA)during pregnancy and its effect on iron metabolism indexes and immune function.Methods A total of 198 pregnant IDA patients admitted to the hospital from January to December 2018 were selected and divided into the control group and observation group according to the random number table method,99 cases in each group.The control group was treated with protein iron succinate oral solution,and the observation group was added with Yixuesheng Capsules on the basis of the control group.Both groups were treated continuously for 4 weeks.Results The total clinical effective rate in the observation group was 97.98%,which was significantly higher than 77.78%of the control group(χ2=18.966,P=0.000).After treatment,the Mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH),and hemoglobin(Hb)were significantly higher than those before treatment(P<0.05);the red blood cell volume distribution wi dth(RDW)was significantly lower than before treatment(P<0.05);the above indicators in the observation group were significantly better than those in the control group(P<0.05).The serum ferritin(SF)and serum iron(SI)levels were significantly higher in both groups than before treatment(P<0.05);the serum transferrin receptor(STFR)and total iron binding capacity(TIBC)levels were significantly lower than those before treatment(P<0.05);the above indicators in the observation group were significantly better than those in the control group(P<0.05);the levels of peripheral blood CD4+,CD8+,CD4+/CD8+were significantly higher than those before treatment(P<0.05),the CD8+level in peripheral blood was significantly lower than before treatment(P<0.05),and the above indicators in the observation group were significantly better than those in the control group(P<0.05).The incidence of adverse reactions during treatment in the observation group was 4.04%,which was equivalent with 3.03%in the control group(χ2=0.148,P=0.700).Conclusion protein iron succinate oral solution combined with Yixuesheng Capsules has significant clinical efficacy in the treatment of IDA during pregnancy,which can obviously improve the symptoms of anemia improve the body’s immune function,and has better safety.