松龄血脉康胶囊联合缬沙坦治疗高血压合并糖尿病肾病患者疗效观察及对肾功能的影响

目的探讨松龄血脉康胶囊联合缬沙坦治疗高血压合并糖尿病肾病患者疗效观察及对肾功能的影响。方法选择高血压合并糖尿病肾病患者118例,采用随机数字表法随机分为观察组59例与对照组59例。两组患者均采用常规处理。对照组给予缬沙坦治疗,观察组在对照组基础上结合松龄血脉康胶囊。两组疗程均为12周。比较两组治疗疗效,治疗前后血压、24 h尿蛋白定量和蛋白排泄率(UAER)和肾功能变化,及不良反应发生情况。结果观察组总有效率(93.22%)高于对照组(74.58%),差异有统计学意义(χ^2=7.59,P<0.05)。两组治疗后舒张压(DBP)、收缩压(SBP)、24 h尿蛋白定量、UAER、血肌酐(Scr)和尿素氮(BUN)水平较治疗前降低(t分别=16.89、20.41、10.66、23.34、19.56、13.80;11.74、10.37、5.90、12.88、8.49、8.33,P均<0.05),且观察组治疗后SBP、DBP、24 h尿蛋白定量、UAER、Scr和BUN水平低于对照组治疗后,差异均有统计学意义(t分别=6.99、6.79、9.43、8.97、11.57、9.28,P均<0.05)。观察组不良反应发生率(5.08%)低于对照组(18.64%),差异有统计学意义(χ^2=5.19,P<0.05)。结论松龄血脉康胶囊联合缬沙坦治疗高血压合并糖尿病肾病患者疗效良好,且对肾脏具有良好保护作用。

Effect of Songling Xuemaikang capsule and valsartan on hypertension complicated with diabetic nephropathy and its influence on renal function

Objective To investigate the effect of Songling Xuemaikang capsule combined with valsartan on hypertensive patients with diabetic nephropathy and its influence on renal function.Methods The 118 patients with hypertension and diabetic nephropathy were randomly divided into observation group(59 cases)and control group(59 cases).Both groups were received routine treatment.The control group was treated with valsartan,while the observation group was treated with Songling Xuemaikang capsule on the basis of the therapy of control group.The course was 12 weeks.The therapeutic effects,blood pressure,24-hour urinary protein quantification,UAER,renal function and adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the observation group(93.22%)was higher than that of the control group(74.58%)(χ^2=7.59,P<0.05).After treatment,SBP,DBP,24-hour urine protein quantity,UAER,Scr and BUN levels in the two groups were lower than those before treatment(t=16.89,20.41,10.66,23.34,19.56,13.80;11.74,10.37,5.90,12.88,8.49,8.33,P<0.05).After treatment,the SBP,DBP,24-hour urine protein quantity,UAER,Scr and BUN levels in the observation group were lower than those in the control group(t=6.99,6.79,9.43,8.97,11.57,9.28,P<0.05).The incidence of adverse reactions in the observation group(5.08%)was lower than that in the control group(18.64%)(χ^2=5.19,P<0.05).Conclusion Songling Xuemaikang capsule combined with valsartan has a good therapeutic effect on patients with hypertensive complicated with diabetic nephropathy,with good protective effect for the kidney.