依达拉奉联合醒脑静注射剂对颅脑损伤患者凝血功能及脑脊液NSE、ET-1、CRP和PCT的影响

目的探讨依达拉奉联合醒脑静注射剂对颅脑损伤患者凝血功能及脑脊液神经元特异性烯醇化酶(NSE)、内皮素-1(ET-1)、C反应蛋白(CRP)和降钙素原(PCT)水平的影响。方法选择2018年3月至2019年3月期间收治的颅脑损伤患者102例,采用随机数字表法随机分为观察组与对照组,各51例。对照组给予依达拉奉注射剂30 mg+0.9%氯化钠注射剂100 mL,iv gtt,qd;观察组在对照组基础上给予醒脑静注射剂20 mL+0.9%氯化钠注射剂250 mL,iv gtt,bid。2组疗程均为4周。比较2组治疗疗效,治疗前后神经功能缺损程度(NIHSS)评分、精神状态(MMSE)评分、凝血功能、NSE、ET-1、CRP和PCT水平变化,及不良反应和预后情况。结果观察组治疗后NIHSS评分低于对照组,而MMSE评分高于对照组(t=9.845、5.961,P<0.05)。观察组治疗后D-二聚体和Fib水平低于对照组(t=12.153、11.412,P<0.05),脑脊液NSE、ET-1、CRP和PCT水平低于对照组(t=14.849、15.476、20.122、15.915,P<0.05)。2组均未发生明显不良反应。观察组预后结局优于对照组(P<0.05)。结论依达拉奉联合醒脑静注射剂对颅脑损伤患者效果良好,可改善患者凝血功能,降低脑脊液NSE、ET-1、CRP和PCT水平,值得临床借鉴。

Effects of edaravone combined with Xingnaojing injection on coagulation function and cerebrospinal fluid NSE,ET-1, CRP and PCT in patients with craniocerebral injury

AIM To investigate the effects of edaravone combined with Xingnaojing injection on coagulation function and neuron specific enolase(NSE),endothelin-1(ET-1),C-reactive protein(CRP)and procalcitonin(PCT)in patients with craniocerebral injury.METHODS A total of 102 patients with craniocerebral injury ad-mitted to our hospital from March 2018 to March 2019 were randomly divided into observation group(51 patients)and control group(51 patients)by random number table method.The control group was given edaravone injection 30 mg+0.9%sodium chloride injection 100 mL,iv gtt,qd;the observation group was given Xingnaojing injection 20 mL+0.9%sodium chloride injection 250 mL,iv gtt,bid.The course of treatment was 4 weeks in both groups.The therapeutic effects,NIHSS score and MMSE score,coagulation function,changes of NSE,ET-1,CRP and PCT before and after treatment,and adverse drug reactions and prognosis were compared between the 2 groups.RESULTS After treatment,the NIHSS score of the observation group was lower than that of the control group,while the MMSE score was higher than that of the control group(t=9.845,5.961,P<0.05).The levels of D-dimer and Fib in the observation group were lower than those in the control group(t=12.153,11.412,P<0.05).The levels of NSE,ET-1,CRP and PCT in cerebrospinal fluid of the observation group were lower than those of the control group after treatment(t=14.849,15.476,20.122,15.915,P<0.05).There were no obvious adverse drug reactions in both groups.The prognosis of the observation group was better than that of the control group(P<0.05).CONCLUSION Edaravone combined with Xingnaojing injection has a good effect on patients with craniocerebral injury,and it can improve the coagulation function and reduce the levels of NSE,ET-1,CRP and PCT in cerebrospinal fluid,which is worthy of clinical reference.