SLP-2在胃癌中的表达及意义

目的:研究SLP-2基因在胃腺癌及正常胃黏膜中的表达情况.方法:应用免疫组织化学法及RT-PCR法分别检测45例及40例胃腺癌及其癌旁正常胃黏膜中SLP-2基因的表达,并结合免疫组织化学结果及胃癌患者的临床病理资料进行分析.结果:免疫组织化学和RT-PCR结果均显示SLP-2在胃腺癌组织中的表达高于正常配对胃黏膜(68.9%vs26.7%,1.12±0.47vs0.63±0.31,均P<0.01),且SLP-2的表达与胃癌TNM分期及有无淋巴结转移相关(2=5.32、4.78,均P<0.05).结论:SLP-2基因在胃腺癌组织中高表达,可能参与胃腺癌的发生发展和转移.

Significance of SLP-2 expression in gastric adenocarcinoma

AIM:To investigate the expression of stomatinlike protein 2(SLP-2) in gastric adenocarcinoma and to analyze its significance.METHODS:The expression of SLP-2 mRNA and protein was detected by RT-PCR in 40 cases and by immunohistochemistry in 45 cases of human gastric adenocarcinoma and adjacent tumor-free tissue,respectively.The relationship between SLP-2 expression and clinicopathologic characteristics of gastric adenocarcinoma was then analyzed.RESULTS:The expression of SLP-2 mRNA and protein in gastric adenocarcinoma was significantly higher than that in adjacent tumor-free tissue(68.9% vs 26.7%,1.12 ± 0.47 vs 0.63 ± 0.31,both P < 0.01).SLP-2 expression in gastric adenocarcinoma was associated with lymph node metastasis and TNM stage(2 = 5.32,4.78,both P < 0.05),but not with other clinicopathologic characteristics(all P > 0.05).CONCLUSION:The expression of SLP-2 is increased in gastric adenocarcinoma.SLP-2 may play important roles in the occurrence,development and metastasis of gastric adenocarcinoma.