高血压患者动态动脉僵硬指数与血压变异性的关系

目的探讨高血压患者动态动脉僵硬指数(AASI)与血压变异性(BPV)的关系。方法入选2009-03-2011-10中国医科大学附属第一医院就诊的高血压患者119例,所有患者均行24h动态血压监测。AASI定义为1减去24h舒张压和收缩压的回归系数。依据AASI水平,分为4组:AASI<0.30、0.30～<0.41、0.41～<0.52、≥0.52。结果相关性分析显示,AASI分别与年龄(r=0.301,P<0.01)、24h收缩压(r=0.276,P=0.001)、白昼收缩压(r=0.225,P=0.008)、夜间收缩压(r=0.366,P<0.01)、24h脉压(r=0.510,P<0.01)、24h收缩压标准差(r=0.297,P=0.001)呈正相关,而与24h舒张压标准差(r=-0.256,P=0.002)、24h平均心率标准差(r=-0.205,P=0.017)及24h平均动脉压标准差(r=-0.202,P=0.017)呈负相关。多元线性逐步回归分析显示,AASI与24h脉压和24h收缩压标准差呈正相关(β=0.321,β=0.725,均P<0.01),与24h舒张压标准差和24h平均动脉压标准差呈负相关(β=-0.428,β=-0.346,均P<0.01)。结论 AASI与BPV密切相关。

Association of ambulatory arterial stiffness index with blood pressure variability in hypertensives

Objective To investigate the relationship between ambulatory arterial stiffness index (AASI) and blood pressure variability (BPV) in patients with hypertension. Methods A total of 119 hypertensives from First Affiliated Hospital of China Medical University between March 2009 and October 2011 were enrolled in this study. All the cases underwent 24-h ambulatory blood pressure monitoring. AASI was defined as one minus the regression slope of 24-h diastolic on systolic blood pressure. The subjects were divided into four groups: AASI<0.30, 0.30-0.41, 0.41-0.51, ≥0.52 according to the levels of AASI. Results Correlation analysis indicated that AASI was positively correlated with age (r=0.301, P<0.01), 24-hour systolic blood pressure(24hSBP, r=0.276, P=0.001), day systolic blood pressure (dSBP, r=0.225, P=0.008), night systolic blood pressure (nSBP, r=0.366, P<0.01), 24-hour pulse pressure (24hPP, r=0.510, P<0.01), and 24-hour systolic blood pressure standard deviation (24hSBPSD, r=0.297, P=0.001); but negatively associated with 24-hour diastolic blood pressure standard deviation (24hDBPSD, r=-0.256, P=0.002), 24-hour average heart rate standard deviation (24hHRSD, r=-0.205, P=0.017), and 24-hour mean arterial pressure standard deviation (24hMAPSD, r=-0.202, P=0.017). AASI showed positive relevance with 24hPP and 24hSBPSD (β=0.321, β=0.725, all P<0.01), while reverse correlation with 24hDBPSD and 24hMAPSD (β=-0.428, β=-0.346, all P<0.01) by multiple linear stepwise regression analysis. Conclusion AASI is closely related to blood pressure variability.