喹诺酮类抗菌药的应用及其耐药性分析

目的:分析我院住院患者的喹诺酮类抗菌药环丙沙星(CIP)、左氧氟沙星(LEV)的临床应用情况,为合理使用抗菌药物提供依据.方法:回顾性分析2008年1月-2010年12月CIP、LEV的总消耗金额、用药频度(DDDs)、日治疗费用(DDC)和病原菌耐药性资料.结果:喹诺酮类抗菌药的总消耗金额、用药频度均为LEV排第一.CIP排第二;日治疗费用为LEV低于CIP;细菌耐药率的差别不显著,但大部分病原菌耐药情况与前几年相比均有明显好转.结论:喹诺酮类抗菌药的使用情况及大部分细菌耐药性均有明显改善,喹诺酮类抗菌药临床使用趋于合理.

Analysis on Application of Quinolone Antibiotics and Bacterial Drug Resistance

Objective： To analyze clinical application of quinolone antibiotics ciprofloxacin （CIP） and levofloxacin （LEV） to provide evidence for reasonable using of antibiotics. Methods： The total consumption amount of DDDs, at the cost of DDC and pathogen resistance of CIP and LEV in our hospital were analyzed retrospectively from Jan 2008 to Dec 2010. Result： LEV ranked first at the total amount of consumption, DDDs of quinolone antibiotics during the survey period and CIP ranked second. The DDC of LEV was lower than that of CIP. Bacterial drug resistance rates were not significant difference during the survey period, but most pathogenic bacteria and drug resistances improved significantly compared to previous years. Conclusion： The use of quinolone antibiotics and most of bacterial drug resistances has been significantly improved, suggesting that clinical use of quinolone antibiotics become more reasonable.