高血压左心室肥厚患者结缔组织生长因子和B型钠尿肽的变化及临床意义

目的观察原发性高血压左心室肥厚(left ventricular hypertrophy,LVH)患者结缔组织生长因子(CTGF)及B型钠尿肽(BNP)含量的变化并探讨其临床意义。方法选择120例高血压患者,分为LVH组62例和未合并LVH组(NLVH组)58例,另选择健康体检者30例为对照组。采用酶联免疫吸附法测定血清CTGF和血浆BNP的含量。采用彩色多普勒超声检查各组心脏舒张期室间隔厚度、左心室后壁厚度、左心室舒张末内径及LVEF。结果与对照组比较,NLVH组患者左心室质量指数明显升高(P<0.01),血清CTGF和血浆BNP比较,差异无统计学意义(P>0.05);LVH组血清CTGF和血浆BNP含量及左心室质量指数均明显升高,差异有统计学意义(P<0.01),且血清CTGF和血浆BNP含量与左心室质量指数呈正相关(r=0.51,r=0.64,P<0.01),NLVH组血清CTGF和血浆BNP含量与左心室质量指数比较差异无统计学意义(P>0.05)。结论血清CTGF和血浆BNP含量监测,对高血压LVH患者的诊治和预后判断具有重要临床意义。

Levels of CTGF and BNP and clinical significance in hypertensive patients with left ventricular hypertrophy

Objective To investigate the changes of the serum connective tissue growth factor (CTGF) and plasma brain natriuretic peptide(BNP) concentration in hypertensive patients with left ventricular hypertrophy(LVH) and their clinical significance.Methods The serum CTGF, plasma BNP,interventricular septum thickness(IVST),left ventricular posterior wall thickness (PWT),left ventricular end diastolic diameter(LVEDD) and LVEF were measured in 120 hypertensive patients including 62 LVH and 58 non-LVH,and 30 controls.Results The CTGF,BNP levels and left ventricular mass index(LVMI) were higher in hypertensive patients with LVH than in healthy people(P<0.01).CTGF and BNP were positively correlated with LVMI in patients with LVH.No difference in CTGF,BNP and LVMI was seen between non-LVH group and healthy people(P>0.05).Conclusion The levels of serum CTGF and plasma BNP have important significance in diagnosis,treatment and judging prognosis of hypertensive patients with left ventricular hypertrophy.