左旋氨氯地平和氨氯地平治疗轻中度高血压的临床观察

目的评价左旋氨氯地平和氨氯地平治疗轻中度高血压的疗效与不良反应。方法选择门诊轻中度高血压患者108例,随机分为3组,每组36例,接受氨氯地平5 mg/d(A组)、左旋氨氯地平2.5 mg/d(B组)、左旋氨氯地平5 mg/d(C组),共治疗8周,观察降压效果和不良反应。结果 3组治疗后收缩压和舒张压较治疗前明显下降(P<0.05)。与A、B组比较,C组血压变化值更高(P<0.01),血压达标率高(P<0.05)。3组治疗后红细胞计数、血红蛋白较治疗前明显增高(P<0.05);B组血K~+明显降低(P<0.05)。结论左旋氨氯地平能有效降低轻中度高血压患者的血压,不良反应低于氨氨地平,左旋氨氯地平2.5 mg治疗后血K+下降。

Clinical observation of levamlodipine and amlodipine in treatment of patients with mild to moderate essential hypertension

Objective To evaluate the clinical effectiveness and adverse reactions of levamlodipine and amlodipine in treatment of patients with mild to moderate hypertension.Methods 108 outpatients with mild to moderate hypertension were divided into three groups randomly:amlodipine, 5 mg/d(group A),levamlodipine,2.5 mg/d(group B) and levamlodipine,5 mg/d(group C).The patients were treated for 8 weeks,antihypertensive effect and adverse reactions were observed. Results Systolic and diastolic blood pressure values were decreased significantly in 3 groups after treatment compared with before treatment(P<0.05).Changes in blood pressure values were greater(P<0.01) and rate of attaining target blood pressure was higher(P<0.05) in group C compared with groups A and B.Hemoglobin and red blood cell count increased after treatment in 3 groups(P<0.05).Serum potassium decreased in group B(P<0.05).Conclusion In the treatment of senile hypertension,levamlodipine is more effective and has fewer adverse reactions than amlodipine.After levamlodipine 2.5 mg treatment,serum potassium is decreased.