降压达标干预对原发性高血压患者臂踝脉搏波传导速度的影响

目的 探讨原发性高血压患者降压干预对臂踝脉搏波传导速度(baPWV)的影响.方法 150例高血压患者接受包括缬沙坦80 mg/d在内的降压治疗6个月降压达标定义为＜140/90 mm Hg(1 mm Hg=133 kPa)]和正常对照组135例,应用欧姆龙-VP1000自动测量baPWV,对其进行标准化的心血管病危险因素调查、体格检查及实验室检查.结果 高血压组baPWV为(2105.8±378.4)cm/s,高于正常对照组的(1371.5±1 76.5)cm/s(t=4.05,P＜0.001).高血压组和对照组的动脉硬化的检出率分别为82.0%和21.8%;高血压组患者的年龄(r=0.51,P＜0.001)、收缩压(r=0.53,P＜0.001)、脉压、(r=0.43,P＜0.05),脉压指数(PPI)(r=0.51,P＜0.05)、空腹血糖(r=0.39,P＜0.01)均与baPWV呈正相关;高血压组的baPWV由(2105.8±378.4)cm/s降低至(1704.2±332.0)cm/s(t=3.85,P＜0.05).降压达标组的baPWV(1588.8±278.7)cm/s]明显低于未达标组(1857.7±324.9)cm/s(t=3.67,P＜0.001)].结论 年龄和收缩压是高血压患者baPWV的主要影响因素,降压达标可以改善baPWV,减轻动脉僵硬度.

Abstract：

Objective To investigate the effect of antihypertensive therapy on brachial-ankle pulse wave velocity (baPWV) in patients with essential hypertension (EH). Methods The 150 EH patients (EH group)receiving antihypertensive therapy with valsartan 80 mg/d, and 135 healthy controls (control group) were enrolled in this study. Automatic pulse wave velocity (PWV)measurement system was employed to examine baPWV, and the investigation about cardiac risk factors, physical and laboratory examination was performed. The baPWV was used as an index to show artery stiffness.Results The baPWV was significantly higher in EH group than in control group (2105.8±378.4) cm/svs. (1371.5±176.5) cm/s, t=4.05, P＜0.001]. The detection rate of atherosclerosis was 82.0% and 21.8% in EH and control group respectively. In EH group, there were positive relationships between age and baPWV (r= 0.51, P＜0. 001), SBP and baPWV (r=0.53, P＜0.001), pulse pressure (PP) and baPWV (r=0.43, P＜0. 05), PP index (PPI) and baPWV (r=0.51, P＜0.05), blood glucose and baPWV (r=0.39, P＜0.01). The baPWV decreased significantly from (2105.8±378.4) cm/s to (1704.2±332.0) cm/s (t=3.85, P＜0. 05) in EH group. The baPWV was significantly lower in the subgroup with a target BP than without a target BP in EH patients (1588.8±278.7) vs. (1857.7±324.9) cm/s, t=3.67, P＜0.001].Conclusions The age and SBP are primary risk factors for baPWV in EH patients. The antihypertensive therapy can relieve baPWV with a target blood pressure.

Effect of antihypertensive therapy on brachial-ankle pulse wave velocity in patients with essential hypertension

Objective To investigate the effect of antihypertensive therapy on brachial-ankle pulse wave velocity (baPWV) in patients with essential hypertension (EH). Methods The 150 EH patients (EH group)receiving antihypertensive therapy with valsartan 80 mg/d, and 135 healthy controls (control group) were enrolled in this study. Automatic pulse wave velocity (PWV)measurement system was employed to examine baPWV, and the investigation about cardiac risk factors, physical and laboratory examination was performed. The baPWV was used as an index to show artery stiffness.Results The baPWV was significantly higher in EH group than in control group (2105.8±378.4) cm/svs. (1371.5±176.5) cm/s, t=4.05, P＜0.001]. The detection rate of atherosclerosis was 82.0% and 21.8% in EH and control group respectively. In EH group, there were positive relationships between age and baPWV (r= 0.51, P＜0. 001), SBP and baPWV (r=0.53, P＜0.001), pulse pressure (PP) and baPWV (r=0.43, P＜0. 05), PP index (PPI) and baPWV (r=0.51, P＜0.05), blood glucose and baPWV (r=0.39, P＜0.01). The baPWV decreased significantly from (2105.8±378.4) cm/s to (1704.2±332.0) cm/s (t=3.85, P＜0. 05) in EH group. The baPWV was significantly lower in the subgroup with a target BP than without a target BP in EH patients (1588.8±278.7) vs. (1857.7±324.9) cm/s, t=3.67, P＜0.001].Conclusions The age and SBP are primary risk factors for baPWV in EH patients. The antihypertensive therapy can relieve baPWV with a target blood pressure.