新疆维、汉、哈族成年人群代谢综合征与颈动脉内中膜厚度的关联性研究

目的探讨新疆维、汉、哈族成年人群代谢综合征(MS)与颈动脉内中膜厚度(IMT)的关联性。方法采用整群抽样的流行病学调查的方法进行抽样调查15061人,实际共完成14618人。根据MS的诊断标准分为MS患病组(MS组,3356例)与非患病组(非MS组,11262例)。对所有患者均记录体重、身高、吸烟史、收缩压、舒张压,并测定其血糖、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),计算其体重指数(BMI)等;同时完成颈动脉IMT等动脉硬化指标的测量,应用SPSS11.0统计软件分析不同民族MS患病率,同时分析MS与IMT的关联性。结果对于受检人群总体,MS组IMT值显著高于非MS组[(0.077±0.030)cmvs.(0.072±0.030)cm,t=-9.239,P<0.001]。维族、汉族、哈族MS组的IMT值均显著高于非MS组(t=-5.80,P<0.001;t=-6.877,P<0.001;t=-2.805,P=0.005)。经校正年龄、性别等影响因素后,总体人群及维族、汉族的MS组与非MS组IMT仍有显著差异(P均<0.05),哈族两组间IMT无统计学差异(P=0.371)。结论对于新疆维、汉族人群,MS可以增加动脉粥样硬化发生的风险,对哈族人群的IMT无明显影响,对MS患者及早进行颈动脉的超声检查,将有助于心血管病事件的一级预防。

Relevance study of metabolic syndrome and intima-media thickness(IMT)of carotid artery in Han,Uighur and Kazakh population of Xinjiang

Objective The aim of this study was to investigate the association of metabolic syndrome and intima-media thickness （IMT） of carotid artery in Han, Uighur and Kazakh population of Xinjiang. Methods This cross-section study was performed in 15 061 people aged 35 and over years old at Xinjiang by using a four-stage selected random sampling method, and 14 618 people accepted in facts. All the subjects was divided into two groups, the metabolic syndrome group （ MS group） and the non-metabolic syndrome group （non-MS group）. All the patients underwent recoding of smoking, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, body mass index （BMI）, total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C）, the intima-media thickness（IMT） of carotid arteries were measured by non-invasive method. SPSS 11.0 software package was used for the analysis. The prevalence of metabolic syndrome in different nations was analyzed. The association of metabolic syndrome and intima-media thickness （IMT） of carotid artery were analyzed. Results To the whole subjects, the IMT of MS group was higher （0. 077 ± 0. 030） cm versus （0. 072 ± 0. 030） cm （P 〈 0. 05） than the non-MS group. The IMT of MS groups in Han, Uighur, and Kazakh people was higher. Results did show statistical difference between the two group （ t = - 5. 80, P 〈 0. 001 ; t =- - 6. 877,P 〈 0. 001 ; t = - 2. 805, P = 0. 005 ）. After correcting the factors of age and sex, results did show statistical difference between the two group in han and Uighur （ P 〈 0. 05 ）. But there is no statistical difference in Kazakh （P = 0. 371 ）. Conclusions The results of this study showed that metabolic syndrome raises the risk of atherosclerosis in Han, and Uighur population of Xinjiang. But it has no conspicuous effect in Kazakh population. The sonography of carotid artery as early as possible is helpful for primary prevention of cardiovascular events in the patients of metabolic syndrome.