亚裔女性乳腺癌危险因素的Meta分析

目的 综合评价亚裔女性乳腺癌的危险因素及关联强度,为建立风险预测模型提供依据.方法 系统地收集1995-2010年亚裔女性乳腺癌危险因素的相关研究文献;按照NOS标准对纳入文献进行质量评价;采用RevMan 4.2软件进行数据分析,得到合并的OR值及其95%CI.结果 纳入合格研究文献27篇,共计研究对象403 170例.文献质量评价A级文献20篇、B级文献7篇,纳入文献质量较高;有统计学意义的乳腺癌危险因素依次为流产次数≥3次、有乳腺癌家族史、初产年龄≥30岁、吸烟、未生育史、未哺乳史、初潮年龄≤12岁和饮酒,OR值分别为3.00(95%CI: 1.68～5.36)、2.39(95%CI:1.78～3.21)、1.54(95%CI: 1.30～1.82)、1.50(95%CI:1.03～2.20)、1.48(95%CI:1.20～1.83)、1.29(95%CI:1.12～1.47)、1.26(95%CI:1.07～1.49)和1.16(95%CI:1.01～1.32).结论 流产次数≥3次、有乳腺癌家族史、初产年龄≥30岁、吸烟、未生育史、未哺乳史、初潮年龄≤12岁和饮酒是建立亚裔女性乳腺癌风险预测模型首要考虑的危险因素.

Abstract：

Objective To evaluate the risk factors of breast cancer in Asian women and to provide evidences for establishing a risk assessment model. Methods Published studies concerning risk factors of breast cancer in Asian women were searched systemically and assessed by NOS (Newcastle-Ottawa Scale) items between 1995 and 2010. RevMan 4.2 software was used for data analysis and for calculating OR and its 95%CI on every risk factor. Results 27 studies including 403170 women were selected for Meta-analysis. According to NOS items, 20 studies were classified as A degree and 7 studies were evaluated as B degree. The risk factors of breast cancer and its pooled odds ratio values with statistical significance were as follows: 3.00 (95%CI: 1.68-5.36) when number of abortions≥3; 2.39 (95%CI: 1.78-3.21 ) when with family history of breast cancer; 1.54(95%CI: 1.30-1.82) when age at first live birth ≥30 (year); smoking was 1.50(95%CI: 1.03-2.20); 1.48(95%CI:1.20-1.83) with no live births; 1.29 (95%CI: 1.12-1.47) with no breast feeding; 1.26 (1.07-1.49)with age at menarche ≤12 (year) and 1.16(95%CI: 1.01-1.32) with alcohol drinking. Conclusion Number of abortions≥3, family history of breast cancer, age at first live birth ≥30 (year) ,smoking, no live births, no breast feeding, age at menarche ≤ 12 (year), and alcohol drinking were among the priorities in the establishment of breast cancer risk assessment model for Asian women.

Risk factors of breast cancer in Asian women: a meta-analysis

Objective To evaluate the risk factors of breast cancer in Asian women and to provide evidences for establishing a risk assessment model. Methods Published studies concerning risk factors of breast cancer in Asian women were searched systemically and assessed by NOS (Newcastle-Ottawa Scale) items between 1995 and 2010. RevMan 4.2 software was used for data analysis and for calculating OR and its 95%CI on every risk factor. Results 27 studies including 403170 women were selected for Meta-analysis. According to NOS items, 20 studies were classified as A degree and 7 studies were evaluated as B degree. The risk factors of breast cancer and its pooled odds ratio values with statistical significance were as follows: 3.00 (95%CI: 1.68-5.36) when number of abortions≥3; 2.39 (95%CI: 1.78-3.21 ) when with family history of breast cancer; 1.54(95%CI: 1.30-1.82) when age at first live birth ≥30 (year); smoking was 1.50(95%CI: 1.03-2.20); 1.48(95%CI:1.20-1.83) with no live births; 1.29 (95%CI: 1.12-1.47) with no breast feeding; 1.26 (1.07-1.49)with age at menarche ≤12 (year) and 1.16(95%CI: 1.01-1.32) with alcohol drinking. Conclusion Number of abortions≥3, family history of breast cancer, age at first live birth ≥30 (year) ,smoking, no live births, no breast feeding, age at menarche ≤ 12 (year), and alcohol drinking were among the priorities in the establishment of breast cancer risk assessment model for Asian women.