混合糖对老年创伤后患者糖代谢和炎性反应影响的随机对照研究

目的 评价混合糖对腹部手术后老年患者血糖、胰岛功能以及炎性反应的影响. 方法采用前瞻、随机、双盲、对照的研究方法.满足方案入选标准并获得知情同意的腹部手术后老年患者共40例进入本研究.术后1～2 d开始研究组患者空腹静脉输注混合糖(葡萄糖:果糖:木糖醇为4∶2∶1)电解质注射液1000 ml,对照组患者静脉输注10%葡萄糖注射液1000 ml加15%氯化钾10 ml和10%氯化钠10 ml,连续3 d.观察血糖和胰岛素、胰岛素C肽的变化,同时观察炎性反应因子白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和C反应蛋白(CRP)的变化,以及全身炎性反应综合征(SIRS)发生率. 结果腹部手术后研究组输注混合糖后第2天和第3天血糖升高幅度明显低对照组(4.40±2.58)mmol/L对(14.97±3.44)mmol/L,t=2.984,P=0.008和(2.70±1.55)mmol/L对(8.11±2.60)mmol/L,t=5.659,P=0.000];血胰岛素和胰岛素C肽水平变化两组结果相似;输注不同糖类液体时,第3天研究组 IL-6和TNF-α结果明显低于对照组,组间比较差异有统计学意义IL-6(21.76±10.40)ng/L对(50.17±35.24)ng/L,t=-2.447,P=0.034;TNF-α(23.92±14.89)ng/L对(51.48±42.81)ng/L,t=-2.268,P=0.043],研究组术后发生SIRS 6例,感染并发症4例;对照组分别有8例和6例. 结论适量应用混合糖对创伤后老年患者血糖影响较小,有可能减轻机体炎症反应和减少SIRS和感染并发症的发生.

Abstract：

Objective To evaluate the effects of a carbohydrate-electrolyte solution on serum glucose, pancreas islet function and inflammatory response in elderly patients after abdominal operation.Methods It was a prospective, randomized, double-blinded and controlled trial. Totally 40 elderly patients after abdominal operation who met the defined criteria were enrolled. The subjects in study group were administered with 1000 ml carbohydrate-electrolyte solution intravenously in consecutive three days since 1st or 2nd postoperative day. Control group was administered with 1000 ml of 10% glucose on the same method. The changes of serum glucose, insulin, C-peptide and inflammatory response cytokine (IL-6, TNF-α, CRP) were detected before and after injection.Systemic inflammatory response syndrome (SIRS) was observed.Results All the 40 patients completed the study according to the study protocol. The incremental rate of serum glucose was significantly lower in study group than in control group on the 2nd and 3rd day after administration (4.40±2.58) mmol/L vs. (14.97±3.44) mmol/L, t=2.984, P=0.008; (2.70± 1.55) mmol/L vs. (8.11± 2.60) mmol/L, t= 5.659, P= 0.000]. The changes of insulin and C-peptide of two group were similar before and after operation. The levels of IL-6 and TNF-α were significantly lower in study group than in control group on the 3rd day after administrationIL-6: (21.76±10.40) ng/Lvs. (50.17±35.24) ng/L, t=-2.447, P=0.034; TNF-α:(23.92±14.89) ng/L vs. (51.48±42.81) ng/L, t=-2.268, P=0.043]. In study group, 6 cases experienced SIRS and 4 cases had infective complications, but in control group the numbers were 8 and 6 respectively.Conclusions Appropriate application of carbohydrate-electrolyte solution intravenously has relatively mild effects on serum glucose and inflammatory response cytokine in elderly patients after abdominal operation, it decreases incidence of SIRS and maybe decrease infective complications.

Effect of a carbohydrate-electrolyte solution on glycometabolism and inflammatory response in elderly patients after abdominal operation: a double-blind randomized controlled trial

Objective To evaluate the effects of a carbohydrate-electrolyte solution on serum glucose, pancreas islet function and inflammatory response in elderly patients after abdominal operation.Methods It was a prospective, randomized, double-blinded and controlled trial. Totally 40 elderly patients after abdominal operation who met the defined criteria were enrolled. The subjects in study group were administered with 1000 ml carbohydrate-electrolyte solution intravenously in consecutive three days since 1st or 2nd postoperative day. Control group was administered with 1000 ml of 10% glucose on the same method. The changes of serum glucose, insulin, C-peptide and inflammatory response cytokine (IL-6, TNF-α, CRP) were detected before and after injection.Systemic inflammatory response syndrome (SIRS) was observed.Results All the 40 patients completed the study according to the study protocol. The incremental rate of serum glucose was significantly lower in study group than in control group on the 2nd and 3rd day after administration (4.40±2.58) mmol/L vs. (14.97±3.44) mmol/L, t=2.984, P=0.008; (2.70± 1.55) mmol/L vs. (8.11± 2.60) mmol/L, t= 5.659, P= 0.000]. The changes of insulin and C-peptide of two group were similar before and after operation. The levels of IL-6 and TNF-α were significantly lower in study group than in control group on the 3rd day after administrationIL-6: (21.76±10.40) ng/Lvs. (50.17±35.24) ng/L, t=-2.447, P=0.034; TNF-α:(23.92±14.89) ng/L vs. (51.48±42.81) ng/L, t=-2.268, P=0.043]. In study group, 6 cases experienced SIRS and 4 cases had infective complications, but in control group the numbers were 8 and 6 respectively.Conclusions Appropriate application of carbohydrate-electrolyte solution intravenously has relatively mild effects on serum glucose and inflammatory response cytokine in elderly patients after abdominal operation, it decreases incidence of SIRS and maybe decrease infective complications.