CD10 Expression in Colorectal Carcinoma Correlates With Liver Metastasis |
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Authors: | Yoshiya Fujimoto MD Yukihiro Nakanishi MD Shigeki Sekine MD Kimio Yoshimura MD Takayuki Akasu MD Yoshihiro Moriya MD Tadakazu Shimoda MD |
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Institution: | (1) Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan;(2) Department of Surgery, National Cancer Center Hospital, Tokyo, Japan;(3) Pathology Division, National Cancer Center Research Institute, Tokyo, Japan;(4) Cancer Information and Epidemiology Division, National Cancer Center Research Institute, Tokyo, Japan |
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Abstract: | PURPOSE If it were possible to identify the features of primary colorectal carcinoma that were associated with liver metastasis, these
features could be used as predictors of liver metastasis.
METHODS From January 1995 to December 1997, 648 consecutive cases of colorectal carcinoma were recorded at the Department of Surgery,
National Cancer Center Hospital, Tokyo, Japan. We evaluated clinicopathologic and immunohistochemical factors (age, gender,
tumor location, gross type, size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion,
venous invasion, lymph-node metastasis, and expression of CD10, MUC2, and human gastric mucin) in 505 of these patients who
had undergone resection of T2/T3/T4 colorectal carcinomas to clarify the correlation between these factors and liver metastasis.
RESULTS Liver metastases, including unresectable, were detected in 122 patients (24 percent), all of whom had been followed for at
least five years. Univariate analysis revealed that liver metastasis was significantly associated with tumor size, histologic
type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis,
and CD10 expression. Multivariate analysis revealed that invasion deeper than the subserosa, venous invasion, lymph-node metastasis,
and CD10 expression were significantly associated with liver metastases.
CONCLUSIONS CD10 expression in colorectal carcinoma is a good predictor of liver metastasis.
Supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labor and Welfare, Japan. |
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Keywords: | Colorectal carcinoma Liver metastasis Predictive factor CD10 expression Immunohistochemistry |
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