Skin manifestations of Kikuchi-Fujimoto disease: case report and review |
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Authors: | Hung-Rong Yen Pen-Yi Lin Wen-Yu Chuang Min-Lin Chang Cheng-Hsun Chiu |
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Institution: | (1) Division of Paediatric Infectious Diseases, Department of Paediatrics, Chang Gung Children s Hospital, 5 Fu-Shin Street, Kweishan, 333 Taoyuan , Taiwan;(2) Department of Pathology, Chang-Gung Memorial Hospital, Taoyuan, Taiwan;(3) Department of Anatomy and Cell Biology, National Taiwan University, Taiwan |
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Abstract: | Kikuchi-Fujimoto disease (KFD) is a histiocytic necrotising lymphadenitis, which is a benign disease of unknown aetiology. Misdiagnosing KFD as lymphoma or systemic lupus erythematosus is not uncommon due to the similarity of clinical and histopathological features of these diseases. A 12-year-old female suffered from cervical lymphadenopathy, leukocytopenia, fever and especially skin rash. The biopsy of the lymph node was compatible with KFD. The skin biopsy showed interface alterations with vacuolar degeneration of the basal cells suggesting lupus erythematosus; however, the patient did not fulfill the diagnostic criteria for systemic lupus erythematosus. After treatment with acetaminophen, fever subsided and the skin rashes disappeared without relapse during a 10-month follow-up period. Conclusion: the histopathological findings of cutaneous lesions in KFD are usually similar to those observed in the involved lymph nodes. This report suggests that interface change might be one of the pathological features of the cutaneous manifestations of KFD.Abbreviations KFD Kikuchi-Fujimoto disease - SLE systemic lupus erythematosus |
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Keywords: | Histiocytic necrotising lymphadenitis Kikuchi-Fujimoto disease Lupus erythematosus |
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