血清抗精子抗体对体外受精及单精子显微注射的影响

目的:探讨抗精子抗体(AsAb)对常规体外受精(IVF-ET)及卵胞浆内单精子显微注射(ICSI)的受精、胚胎发育、妊娠率的影响。方法:回顾性分析637例IVF-ET及ICSI患者的临床及实验室资料,并将其分为4组,A组:IVF-ET伴AsAb阳性,36例;B组:ICSI伴AsAb阳性,25例;C组:IVF-ET,AsAb阴性,413例;D组:ICSI,AsAb阴性,163例,分析各组受精率、优质胚胎率及妊娠率的差异。结果:A组受精率显著低于其他各组;A组优质胚胎率及妊娠率显著低于C组和D组;B组优质胚胎率及妊娠率与A组无显著性差异。结论:血清抗精子抗体的存在不但影响精子和卵子的结合,同样也影响胚胎的发育及种植,卵胞浆内单精子显微注射可提高受精率,但对提高胚胎质量及妊娠率无意义。

Effect of Anti Sperm Antibody In An In Vitro Fertilization Embryo Transfer Program

Objective:To investigate the effect of anti-sperm antibody on in vitro fertilization-embryo transfer and intracytoplasmic sperm injection.Methods:This study retrospectively analyzed the clinical and laboratory data of 637 cases of IVF-ET and ICSI,all the cases were divided into 4 groups,group A: 36 cases with AsAb received IVF-ET;group B: 25 cases with AsAb received ICSI;group C: 413 cases without AsAb received IVF-ET;group D: 163 cases without AsAb received ICSI.Results:Insemination rate of group A was decreased than other three groups,high quality embryo rate and clinical gestational rate of group A were decreased than group C and group D.Insemination rate of group B were increased than group A but high quality embryo rate and clinical gestational rate had no significant difference than group A.Conclusion:AsAb not only influence the combination of sperm and ovum,but also influence development and implantation of embryo;ICSI helped to insemination.