| 前列腺素E_1前体—全顺式-8,11,14-廿碳三烯酸的合成 |
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| 引用本文： | 陈光文,洪盈,高雅琴.前列腺素E_1前体—全顺式-8,11,14-廿碳三烯酸的合成[J].沈阳药科大学学报,1986(1). |
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| 作者姓名： | 陈光文 洪盈 高雅琴 |
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| 作者单位： | 沈阳药学院有机化学教研室，沈阳药学院有机化学教研室，中国科学院林业土壤研究所 |
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| 摘 要： | 本文报导了以两条路线合成全顺式-8,11,14-廿碳三烯酸。实验证明,在小规模制备时均可获得满意结果。所用原料为长链不饱和脂肪酸混合物(含50～60%γ-亚麻酸)而不必使用γ-亚麻酸纯品。
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| 关 键 词： | γ-亚麻酸 全顺式-8 11 14-廿碳三烯酸及其甲酯 前列腺素E_1 |
THE SYNTHESIS OF PGE_1 PRECURSOR——ALL CIS-8,11,14-EICOSATRIENOIC ACID |
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| Chen Guangwen Hong Ying Gao Yaqin Shenyang College Institute of Forestry of Pharmacy and Pedology.THE SYNTHESIS OF PGE_1 PRECURSOR——ALL CIS-8,11,14-EICOSATRIENOIC ACID[J].Journal of Shenyang Pharmaceutical University,1986(1). |
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| Authors: | Chen Guangwen Hong Ying Gao Yaqin Shenyang College Institute of Forestry of Pharmacy and Pedology |
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| Institution: | Chen Guangwen Hong Ying Gao Yaqin Shenyang College Institute of Forestry of Pharmacy and Pedology |
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| Abstract: | Two synthetic routes for preparing the precursor of prostaglandin E_1-all- cis-8,11,14-eicosatrienoic acid were studied.The starting raw material was a mixture of long chain unsaturated fatty acids containing 50—60% γ-linolenic ac- id instead of pure γ-linolenic acid as cited in the literature.Experimental resu- lt proves that both are satsfactory for small scale preparations. |
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| Keywords: | γ-Linolenic acid All cis-8 11 14-eicosatrienoic acid and methyl ester Prostaglandin E_1 |
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