Emerging MRI Methods in Translational Cardiovascular Research |
| |
Authors: | Moriel H Vandsburger Frederick H Epstein |
| |
Institution: | (1) Department of Biological Regulation, Weizmann Institute of Science, 76100 Rehovot, Israel;(2) Departments of Radiology, Biomedical Engineering, and Cardiovascular Research Center, University of Virginia, PO Box 800759, 480 Ray C. Hunt Drive, Charlottesville, VA 22908, USA |
| |
Abstract: | Cardiac magnetic resonance imaging (CMR) has become a reference standard modality for imaging of left ventricular (LV) structure
and function and, using late gadolinium enhancement, for imaging myocardial infarction. Emerging CMR techniques enable a more
comprehensive examination of the heart, making CMR an excellent tool for use in translational cardiovascular research. Specifically,
emerging CMR methods have been developed to measure the extent of myocardial edema, changes in ventricular mechanics, changes
in tissue composition as a result of fibrosis, and changes in myocardial perfusion as a function of both disease and infarct
healing. New CMR techniques also enable the tracking of labeled cells, molecular imaging of biomarkers of disease, and changes
in calcium flux in cardiomyocytes. In addition, MRI can quantify blood flow velocity and wall shear stress in large blood
vessels. Almost all of these techniques can be applied in both pre-clinical and clinical settings, enabling both the techniques
themselves and the knowledge gained using such techniques in pre-clinical research to be translated from the lab bench to
the patient bedside. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|