| Gel-HA-M纳米复合骨修复材料的抗菌性研究 |
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| 引用本文： | 孙传锋,李全利,周健,尚新华,窦晓晨. Gel-HA-M纳米复合骨修复材料的抗菌性研究[J]. 口腔颌面外科杂志, 2011, 21(5): 330-333. DOI: 10.3969/j.issn.1005-4979.2011.05.007 |
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| 作者姓名： | 孙传锋 李全利 周健 尚新华 窦晓晨 |
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| 作者单位： | 安徽医科大学附属口腔医院,安徽口腔疾病研究省级实验室,安徽省口腔临床医学重点学科,中央与地方共建口腔医学中心实验室,安徽合肥230032 |
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| 基金项目： | 国家自然科学基金资助项目(30772440); 安徽省科技攻关项目(08010302196); 安徽医科大学校科研基金资助项目(2011xkj017) |
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| 摘 要： | 目的:观察新型纳米复合骨修复材料明胶-羟基磷灰石-米诺环素复合物(Gel-HA-M)的抗菌性。方法:以生理盐水作为释药介质,称取0.2 g Gel-HA-M纳米复合骨修复材料做体外缓释实验,并以不含米诺环素的Gel-HA作为对照组。取第1、3、5、7、14、21、26、30天的缓释液,分别对牙龈卟啉单孢菌(Pg)和金黄色葡萄球菌进行体外抑菌实验,以此观察Gel-HA-M纳米复合骨修复材料的抗菌性。结果:Gel-HA-M纳米复合物具有抗菌性,并在第30天时仍具有抗菌性,能够抑制细菌生长。结论:Gel-HA-M纳米复合物能够较长时间地持续缓释米诺环素,对于Pg和金黄色葡萄球菌均具有良好的抑制作用。
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| 关 键 词： | 骨修复材料 明胶 羟基磷灰石 米诺环素 抗菌 |
Novel Gel-HA-M Nanocomposite and Minocycline Release |
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| SUN Chuan-feng,LI Quan-li,ZHOU Jian,SHANG Xin-hua,DOU Xiao-chen. Novel Gel-HA-M Nanocomposite and Minocycline Release[J]. Chinese Journal of Oral and Maxillofacial Surgery, 2011, 21(5): 330-333. DOI: 10.3969/j.issn.1005-4979.2011.05.007 |
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| Authors: | SUN Chuan-feng LI Quan-li ZHOU Jian SHANG Xin-hua DOU Xiao-chen |
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| Affiliation: | SUN Chuan-feng,LI Quan-li,ZHOU Jian,SHANG Xin-hua,DOU Xiao-chen(Hospital of Stomatology,Anhui Medical University,Anhui Provincial Institute of Oral Disease Research,The Key of Oral Clinical Medicine in Anhui Province,Central and Local Governments to Build Oral Medicine Center Lab,Hefei 230032,Anhui Province,China) |
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| Abstract: | Objective: The aim of this study was to test if nanocomposite combined with minocycline would yield antibiotics release.Methods: Normal saline was chosen as release medium.0.2 g nanocomposite Gel-HA-M was suspended in release solution.Nanocomposite Gel-HA without minocycline was used as a control.After 1,3,5,7,14,21,26,30 d respectively,the slow-release liquid was used to test their antibiotic effects against Porphyromonas gingivalis(Pg) and Staphylococcus aureus(S.aureus) in vitro.Results: Gel-HA-M showed ... |
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| Keywords: | bone repair materials gelatin hydroxyapatite minocycline antibacterial |
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