健脾养肝清热利湿法促进乙型肝炎抗原转阴随机平行对照研究

目的]观察健脾养肝清热利湿法促进乙型肝炎抗原转阴疗效。方法]使用随机平行对照方法,将42例住院患者按抛硬币法简单随机分为两组。对照组21例聚乙二醇干扰素(α-2a),180μg/次,每周一次,皮下注射,连用4周。治疗组21例健脾养肝利湿方(黄芪30g,贯众15g,柴胡10g,女贞子15g,绵茵陈30g,丹参10g;气虚加太子参、白术;阴虚加酸枣仁、桑椹子、五味子、旱莲草;血瘀加败酱草、鸡骨草、郁金、田基黄、田七);1剂/d,水煎300m L,早晚口服。连续治疗90d为1疗程。观测临床症状、HBe Ag、HBs Ag、不良反应。连续治疗3疗程,判定疗效。结果]阴性率指标治疗组优于对照组(P0.05)。结论]健脾养肝清热利湿法促进乙型肝炎抗原转阴效果显著,值得推广。

Hepatitis B Antigen Negative Randomized Parallel Group Study Heat and Dampness Affecting the Spleen Liver

Objective]To observe the effects of Spleen and Liver heat and dampness of hepatitis B antigen negative effect.Methods]Random parallel control method, 42 cases of hospitalized patients by coin toss method is simple randomized into two groups. The control group 21 cases of pegylated interferon（α-2a）, 180μg/times weekly subcutaneously once every four weeks. Liver treatment group 21 cases of spleen dampness party（Huangqi30g,Guanzong15 g, Chaihu10 g, Nvzhenzi15 g, Mianyinchen 30 g,Danshen10g; qi plus Taizishen,Baizhu; deficiency plus Suanzaoren,Sangshenzi,Wuweizi, Hanliancao; stasis plus Baijiangcao,Jigucao,Yujin,Tianjihuang,Tianqi）;1/d, decoction 300 m L, sooner or later orally. 90 d is a continuous course of treatment. Observation of clinical symptoms, negative rate indicators adverse reactions. Continuous treatment for 3 courses, to determine efficacy.Results]Negative rate indicators treatment group than the control group（P〈0.05）.Conclusion]Spleen and Liver heat and dampness impact of hepatitis B antigen negative effect is significant, it is worth promoting.