疏肝理脾止泻汤治疗腹泻型肠易激综合征随机平行对照研究

目的]观察疏肝理脾止泻汤治疗腹泻型肠易激综合征疗效。方法]使用随机平行对照方法,将46例门诊及住院患者按掷骰子法简单随机分为两组。对照组23例洛哌丁胺,未成年2mg/次,成人4mg/次,3次/d。治疗组23例疏肝理脾止泻汤(诃子煨、白术、柴胡、陈皮各12g,鸡内金、延胡索、山楂各15g,香附、防风、枳壳各10g,甘草炙5g,麦芽20g,白芍30g),1剂/d,水煎400m L,早晚温服。连续28d为1疗程。观测临床症状、IBS-QOL、HAMA、症候积分、不良反应。连续治疗2疗程,判定疗效。结果]治疗组痊愈18例,显效2例,有效1例,无效2例,总有效率91.30%。对照组痊愈11例,显效3例,有效3例,无效6例,总有效率73.91%。治疗组疗效优于对照组(P0.05)。相关积分两组均有改善(P0.05),治疗组改善优于对照组(P0.05)。结论]疏肝理脾止泻汤治疗腹泻型肠易激综合征效果显著,值得推广。

Liver Spleen Alone Antidiarrheal Soup Treatment of Diarrhea Type Rritable Bowel Syndrome Random Parallel Control Study

Objective]To observe the liver and spleen anti-diarrhea effect soup treatment of diarrhea type irritable bowel syndrome. Methods]Using random parallel control method, the 46 cases of outpatient and inpatient were randomly divided into two groups according to roll the dice method. Control group of 23 cases of loperamide hydrochloride capsule, minor 2 mg/time, adult 4 mg/time, 3 times/d. Treatment group of 23 cases of liver spleen alone antidiarrheal soup（simmer myrobalan, 12 g atractylodes, radix bupleuri, dried tangerine or orange peel, chicken’s gizzard-membrane, yanhusuo, hawthorn 15 g, incense, windproof, orange every 10 g, 5 g main licorice, 20 g of malt, radix paeoniae alba, 30 g）, 1/d, Fried 400 ml water, morning and evening temperature. For four w 1 course of treatment. Observation of clinical symptoms, IBS- QOL, HAMA, symptom integral, adverse reactions. Results]The treatment group（18 cases cured, 2 cases were markedly effective, effective in 1 case, 2 had no effect, the total effective rate was 91.30%. Control group healed in 11 cases, 3 cases were markedly effective, effective in 3, 6 no effect, the total effective rate was 73.91%. The treatment group curative effect is better than that of control group（P〈0.05）. Relevant points in the two groups were improved（P〈0.05）, the treatment group is better than that of control group（P〈0.05）. Conclusion]Liver the principle spleen antidiarrheal soup treatment of diarrhea type irritable bowel syndrome effect is remarkable, is worth promoting.