| 电针干预局灶性脑缺血再灌注大鼠脑缺血区MVD计数与脑梗死体积比实验研究 |
| |
| 引用本文： | 王璐,;王恩龙.电针干预局灶性脑缺血再灌注大鼠脑缺血区MVD计数与脑梗死体积比实验研究[J].实用中医内科杂志,2014(11):16-17. |
| |
| 作者姓名： | 王璐 ;王恩龙 |
| |
| 作者单位： | [1]辽宁中医药大学第一临床学院2011级中医内科缺血性脑血管病防治专业,沈阳110032; [2]辽宁中医药大学附属医院康复中心脑K1科,沈阳110032 |
| |
| 摘 要： | 目的]电针干预脑缺血/再灌注大鼠,观察脑缺血区中脑梗死体积比变化与微血管密度(MVD)数量,为电针治疗脑血管病提供实验根据。方法]选SPF级SD大鼠84只,按随机数字表法随机分为4组,对照组、假手术组、12只/组;模型组、电针组30只/组。改良线栓复制脑缺血/再灌注大鼠模型,运用TTC染色法或SP法,观察并记录脑梗死的体积比变化与微血管的密度(MVD)的数量。结果]对大鼠进行早期电针治疗,能有效改善大鼠脑梗死体积,并对MVD的增加有促进作用,效果在2~3d内明显。结论]电针对治疗脑缺血/再灌注的损伤有明显疗效的原因可能是电针疗法对MVD的增加有促进作用,从而脑梗死的体积减小,缺氧缺血情况的改善,皆与其有关。
|
| 关 键 词： | 电针 局灶性脑缺血 脑血管疾病 微血管密度 缺氧缺血 MVD计数 脑梗死体积比 |
Electroacupuncture Intervention in Focal Cerebral Ischemia Reperfusion in Cerebral Ischemic Rats MVD Count and Cerebral Infarction Volume Ratio of Experimental Study |
| |
| Institution: | WANG Lu, WANG Enlong ( 1 Liaoning University of Traditional Chinese Medicine Research on the 2011 Level of TCM Prevention and Treatment of Ischemic Cerebrovascular Disease in Department of Internal Medicine, First Clinical College of Professional Students,Shenyang 110032, China; 2. Rehabilitation Center of Brain K1 Affiliated Hospital Shenyang 110032, China ) |
| |
| Abstract: | Objective ] Rat cerebral ischemia / reperfusion of electroacupuncture intervention, t o observe the volume ofcerebral ischemia area cerebral infarction than with changes in microvessel densit y （ MVD ） number, provideexperimental basis for electro acupuncture in the treatment of cerebral vascular disease. Method ] Choose class SPF84 SD rats, were randomly divided into 4 groups, control group, sham operation group, 12 rats / group; model group, electro acupuncture group with 30 rats in each group. Modified thread embolism replication cerebral isehemia / reperfusion rat model, using TTC staining method or SP method, observe and record the change of cerebral infarction volume ratio and microvessel density （ MVD ） nu mber. Results]Early electro acupuncture treatment on the rats, can effectively improve the cerebral infarction volume in rats, and increase of MVD can promote, in 2 ～ 3D inobvious effect. Conclusion ] Electroacupunctur e could be electro acupuncture therapy has a promoting effect on theincrease of MVD causes of cerebral ischemia / reperfusion injury treatment has obvious curative effect, and reduce the volume of cerebral infarction, ischemia and hypoxia conditions improve, all relating to. |
| |
| Keywords: | Electroacupuncture Focal cerebral ischemia Cerebral vascular disease Microvesseldensity Hypoxia isehemia MVD count Cerebral infarct volume ratio |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
