奥美拉唑和雷尼替丁对十二指肠溃疡病愈合率和复发率 影响的对比研究

目的 对比奥美担唑和雷尼替丁治疗十二批肠溃疡病近期愈合率和复发率，探索质子泵抑制剂（PPI）与H2受体拮抗剂对防止溃疡病复发的远程疗效。方法 118例经内镜检查证实的性十二指肠溃疡患者，随机分成奥美拉唑组和雷尼替丁组，进行疗效对比。结果 奥美拉唑组和雷尼替丁组4周溃疡愈合率分别为88.3%(68/77)和68.3％（28／41），雷尼替丁组6周溃疡愈合率为90.2%(37/41)。对溃疡愈合的37例进行长程治疗6－12个月，观察用药时间内的溃疡累计复发率。奥美拉唑组1年内累计复发率为5.2?/19)，雷尼替丁组为16.6％（3／16）.结论 奥美拉唑组短程治疗时溃疡愈合率高于雷尼替丁组，而长程治疗时1年累计复发率明显低于雷尼替丁组，由于奥美拉唑对酸抑制程度大而且时间长，因此，临床上可迅速缓解症状，加快溃疡的愈合。

Contrastive study of the healing and relapse rates in duodenal ulcer disease treated with omeprazole and ranitidine

To contrast the healing and relapse rates of duodenal ulcerdisease (DU) treated with omeprazole and ranitidine and study the remote therapy of proton pump inhibitor (PPI) and H2 receptor for the preven tion of relapse of ulcer.Methods 118 patients with DU confirmed by endoscopic examination were randomly divided into two groups:one treated wit h omeprazole and the other with ranitidine,and received short-term therapy at fist for 4～6 weeks.Results The heali ng rates of the both groups within 4 weeks were 88.3% (68/77) and 68.3% (28/41) respectively.The ranitidine group enjoyed a healing rate of 90.2% (37/41) within 6 weeks,and the 37 cases with ulcer healed received long-term maintenance the rapy for 6～12 months.The total relapse rates were counted and confirmed by endoscopic examination during administration.The total relapse rate after one year for the omeprazole group was 5.2% (1/19),while that for the ranitidine group was 16.6%(3/16).Conclusion During the short-term treatment,healing rate in omeprazole group was higher than that in the ranitidine group,while during the long-term treatment,relapse rate for the omeprazole group was much lower than that for the ranitidine group.Therefore,omeprazole,which has greater degree and prolonged effect of suppression of acidity,can be used clinically for faster relief of the symptoms and for better improvement of the healing.