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Standard skin prick testing and sensitization to inhalant allergens across Europe--a survey from the GALEN network |
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| Authors: | Heinzerling L Frew A J Bindslev-Jensen C Bonini S Bousquet J Bresciani M Carlsen K-H van Cauwenberge P Darsow U Fokkens W J Haahtela T van Hoecke H Jessberger B Kowalski M L Kopp T Lahoz C N Lodrup Carlsen K C Papadopoulos N G Ring J Schmid-Grendelmeier P Vignola A M Wöhrl S Zuberbier T |
| Institution: | 1. Department of Dermatology and Allergy, Charité Universitätsmedizin – Berlin, Berlin, Germany;2. Southampton General Hospital, Infection, Inflammation and Repair Division, University of Southampton, Southampton, UK;3. Department of Dermatology and Allergy Center, Odense University Hospital, Odense, Denmark;4. San Raffaele Pisana, Consiglio Nationale delle Ricerche – CNR (Rome), Rome, Italy;5. Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France;6. Voksentoppen BKL, National Hospital, Oslo, Norway;7. Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium;8. Department of Dermatology and Allergy Biederstein, Division of Environmental Dermatology and Allergy GSF, Technical University Munich (TUM), Munich, Germany;9. Department of Otorhinolaryngology, Academic Medical Centre Amsterdam (AMC), Amsterdam, the Netherlands;10. Helsinki University Central Hospital (HUCH), Helsinki, Finland;11. Department of Clinical Immunology and Allergy, Medical University of Lodz (MUL), Lodz, Poland;12. Medical University of Vienna, Vienna, Austria;13. Fundacion Jimenez Diaz, ImmunoAllergy Department, Autonoma University of Madrid, Madrid, Spain;14. Department of Pediatrics, Ulleval University Hospital, Oslo, Norway;15. Allergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens (NKUA), Athens, Greece;16. Department of Dermatology, University Hospital Zurich, Zurich, Switzerland;17. Institute of Internal Medicine and Pneumology, Consiglio Nazionale delle Ricerche – CNR (Palermo), University of Palermo and IBIM-CNR, Palermo, Italy
Prof. A. M. Vignola deceased on 22 December 2004. |
| Abstract: | Skin prick testing (SPT) is the standard method for diagnosing allergic sensitization but is to some extent performed differently in clinical centres across Europe. There would be advantages in harmonizing the standard panels of allergens used in different European countries, both for clinical purposes and for research, especially with increasing mobility within Europe and current trends in botany and agriculture. As well as improving diagnostic accuracy, this would allow better comparison of research findings in European allergy centres. We have compared the different SPT procedures operating in 29 allergy centres within the Global Allergy and Asthma European Network (GA(2)LEN). Standard SPT is performed similarly in all centres, e.g. using commercial extracts, evaluation after 15-20 min exposure with positive results defined as a wheal >3 mm diameter. The perennial allergens included in the standard SPT panel of inhalant allergens are largely similar (e.g. cat: pricked in all centres; dog: 26 of 29 centres and Dermatophagoides pteronyssinus: 28 of 29 centres) but the choice of pollen allergens vary considerably, reflecting different exposure and sensitization rates for regional inhalant allergens. This overview may serve as reference for the practising doctor and suggests a GA(2)LEN Pan-European core SPT panel. |
| Keywords: | European network inhalant allergens standard skin prick testing |
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