间变性大细胞淋巴瘤的临床病理和免疫组织化学分析

目的 了解间变性大细胞淋巴瘤的临床病理特点,免疫表型和生物学行为。方法 对８例ＡＬＣＬ进行临床病理和免疫组织化学ＡＢＣ法观察及随访６－２５个月。结果 ８例ＡＬＣＬ占同期淋巴瘤的４．１％。平均年龄４０岁,男性和女性各４例。皮肤型２例,全身型６例。临床分为Ⅰ期２例,Ⅱ期１例,Ⅲ期５例。

A clinico-pathological and immunohistochemical study on anaplastic large cell lymphoma

Objective To study the clinicopathological characteristics, immunophenotype and biologic behavior of anaplastic large cell lymphoma (ALCL). Methods Clinicopathological and immunohistochemical methods (ABC method) were used to analyse 8 cases of ALCL and followed for 6 to 25 months. Results Eight ALCL patients (4 male and 4 female) accounted for 4.1% of the 195 lymphomas seen from 1994 to 1997. Average age was 40 years. Two tumors were located in the skin, the remainder were systemic. Clinical stage: stage , 2 cases; stage , 1 case; stage , 5 cases. Histopathology: Tumor cells exhibited high pleomorphism and a large amount of mitotic figures. Reactive components (cells) often observed in the background. Immunohistochemical studies found that all tumors reacted positively with CD30 and negatively with CD15. Five cases expressed Tcell's markers(CD3, UCHL1, CD43) and three expressed Bcell markers (CD79a, L26). After chemotherapy, two patients with cutaneous type ALCL had complete remission and survived 14 and 25 months respectively. Of the six systemic cases, three survived for 68 months, the remaining three died at 2 days, 20 days and 18 months after diagnosis. Conclusions This study found that ALCL was a group of lymphomas showing similarity in morphology but diversity in clinical presentation and immunophenotype. Even if the tumor is very responsive to chemotherapy, ALCL remains a high grade malignant lymphoma.