Bilateral Occlusion of Carotid Artery in Awake Hypertensive Rats (SHR-SP) as a Model of Global Cerebral Ischemia |
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| Authors: | N N Lobanova N I Medvedev V I Popov A N Murashev |
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| Institution: | (1) M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia;(2) Institute of Cell Biophysics, Russian Academy of Sciences, Moscow, Russia |
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| Abstract: | Bilateral occlusion of carotid arteries in awake hypertensive rats (SHR-SP) was used as a model of global brain ischemia (duration
of occlusion — until appearance of seizures). In normotensive rats (WKY), no seizures developed over 60 min. We revealed swelling
of mitochondria in dendrites of hippocampal CA1 pyramidal cells, which was more pronounced in SHP-SP than in WKY rats. Blood
pressure and heart rate in SHR-SP rats increased starting from the first minutes of occlusion, while in WKY rats these parameters
remained unchanged. We proved that bilateral occlusion of the carotid arteries in awake SHR-SP rats can be used as an adequate
model of global cerebral ischemia.
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 12, pp. 627–630, December, 2008 |
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| Keywords: | bilateral occlusion of carotid arteries hypertensive rats (SHR-SP) mitochondria of neuronal dendrites hippocampal CA1 area |
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