还原型谷胱甘肽联合苦参碱治疗慢性乙型肝炎的临床观察

目的观察还原型谷胱甘肽联合苦参碱对慢性乙型肝炎的疗效。方法将163例慢性乙型肝炎患者随机分为两组：治疗组83例给予苦参碱及还原型谷胱甘肽。对照组80例给予还原型谷胱甘肽。两组疗程均为8周。观察患者血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、碱性磷酸酶（ALP）、Y-谷氨酰转肽氯酶（Y-GT）、总胆红素（TBil）、透明质酸（HA）、层黏蛋白（LN）、lV型胶原（IV-C）、Ⅲ型胶原（PCⅢ）及门静脉内径（D）值变化情况。结果治疗组治疗后的ALT、AST、ALP、Y—GT、TBil、HA、LN、N-C、PCⅢ均降低．有显著性差异（P〈0.05）。与对照组治疗后比较．改善更明显．P值均〈0．05．差异有统计学意义。治疗组与对照组的有效率为85．54％和675％．P〈0.01．差异有统计学意义。结论还原型谷胱甘肽联用苦参碱治疗慢性乙型肝炎．在改善肝功能、肝纤维化标志物和临床症状方面有协同作用。

Clinical observation on reduced glutathione combined with Matrine in treating chronic hepatitis B patients

Objective To observe the efficacy on reduced glutathione combined with Matrine in treating chronic hepatitis B patients. Methods 163 patients with chronic hepatitis B were randomly divided into two groups： 83 cases of the treatment group was treated by reduced glutathione and matrine. 80 cases of the control group was treated by reduced glutathione, the period of treatment was eight weeks. Alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, alkaline phosphatase （ALP）, r-glutamyl transpeptidase in ammonia- （Y -GT）, total bilirubin （TBil）, hyaluronic acid （HA）, laminin （LN）, IV type collagen （IV-C）, collagen type Ⅲ （PC Ⅲ）of sera from patients and the portal vein diameter （D） were determined. Results The level of ALT, AST, ALP, Y -GT, TBil, HA, LN, IV-C, PC Ⅲ of treatment group decreased after treatment, D value small decreased, there were significant differences （P〈0.05）. As compared with control group, treatment group had more obvious improvements after treatment, there were significant differences （P〈0.05）. The effective rate of treatment group was 85.54%, while control group was 67.5%, there was significant difference （P〈0.01）. Conclusion Reduced glutathione combined with Matrine in treating patients with chronic hepatitis B have collaborative effects in improving liver function, markers of liver fibrosis and clinical symptoms.