吡柔比星联合紫杉醇新辅助化疗治疗局部晚期乳腺癌

目的观察吡柔比星(THP)联合紫杉醇治疗局部晚期乳腺癌的近期疗效及毒副反应.方法 20例局部晚期乳腺癌患者(治疗组)接受THP 50 mg/m2静注,第1天;紫杉醇135 mg/m2,第1、8天静脉点滴.20例患者接受环磷酰胺/阿霉素/5-氟尿嘧啶(CAF)化疗(对照组),5-Fu 500 mg/m2,静脉点滴,第2、9天;ADM 40 mg/m2,静注,第1天;CTX 500 mg/m2,静注,第1、8天.21 d为1周期,连用2周期.结果治疗组有效率80.0%,对照组有效率45.0%,两组差异有显著性(P＜0.05).治疗组心脏毒性显著低于对照组,两组骨髓抑制发生率差异无显著性.结论 THP联合紫杉醇治疗局部晚期乳腺癌疗效较高,不良反应可耐受.

Neoadjuvant chemotherapy with pirarubicin/taxol regiment for the treatment of locally advanced breast cancer

Objective To evaluate the efficacy and toxicity of taxol plus pirarubicin(THP) in the neoadjuvant chemotherapy of locally advanced breast cancer(LABC).Methods Twenty patients with LABC(treating group) were treated with THP 50 mg/m~2,d1;taxol 70 mg/m~2 d1,8.Twenty patients with LABC(control group) were treated with adriamycin(ADM) 40 mg/m~2,d1;Cyclophosphamide(CTX) 500 mg/m~2,d1,8,5-fluoruracil(5-Fu) 500 mg/m~2,d2,9(CAF).Each cycle was 3 weeks,and 2 cycles as 1 course of treatment.Results The CR+PR rate of 80.0 % in the treating group and 45.0% in the control group(P<0.05).The incidence of adverse reactions of cardiac toxicity in the treating group was significantly lower that in the control group.Conclusion THP plus taxol is well tolerated and effective for LABC.