晚期胃肠道恶性肿瘤患者姑息性介入治疗前后焦虑、抑郁及生活质量评分的临床观察

目的通过比较晚期胃肠道肿瘤患者姑息性介入治疗前后焦虑、抑郁及生活质量评分,评价姑息性介入治疗对患者精神、情绪方面的影响。方法入选56例晚期胃肠道恶性肿瘤患者,均采用姑息性动脉灌注化疗或动脉化疗栓塞,治疗前后采用焦虑自评量表(SAS)、抑郁自评量表(SDS)和生活质量量表(FACT-G)进行检测。全部患者进行症状自评量表(SCL-90)评分,并与中国常模进行比较。结果晚期胃肠道恶性肿瘤患者SCL-90各因子评分与中国常模比较,躯体化、抑郁、焦虑因子评分明显升高(P<0.05),姑息性介入治疗后患者SDS及SAS评分明显低于治疗前(P<0.05),生活质量评分(FACT-G)治疗后较治疗前也有显著提高(P<0.05)。结论姑息性介入治疗能够改善晚期胃肠道恶性肿瘤患者抑郁、焦虑症状及生活质量。

Clinical observation on scores of anxiety, depression and quality of life for advanced gastrointestinal carcinoma patients with palliation intervention therapy

Objective To evaluate the influence of palliative intervention therapy on advanced gastrointestinal carcinoma patients with depression and anxiety before and after the treatment. Methods 56 advanced gastrointestinal carcinoma patients were selected and treated with intra-arterial perfusion chemotherapy or intra-arterial perfusion chemotherapy with embolization. Curative effects were assessed with the SDS, SAS and FACT-G before and after the treatment. In addition, all patients took self-assessment with SCL-90, comparing with the Chinese norms. Results SCL-90 scores including the somatization agent,depression agent, and anxiety agent scores of the advanced gastrointestinal carcinoma were higher than those of Chinese norms, with significant difference(P < 0.05). After palliative intervention therapy, the scores of SDS and SAS were lower than those before the palliative intervention therapy with significant difference(P < 0.05); and furthermore with an obvious improvement in the scores of FACT-G(P < 0.05). Conclusion Palliative intervention therapy for advanced gastrointestinal carcinoma patients can improve the complaints of depression anxiety and quality of life.